Beyond Triphosphates: Reagents and Methods for Chemical Oligophosphorylation.
Beyond Triphosphates: Reagents and Methods for Chemical Oligophosphorylation.
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DOI：
10.1021/jacs.1c07990
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发表时间：
2022-05-04
影响因子：
15
通讯作者：
Cummins, Christopher C.
中科院分区：
文献类型：
--
作者：
Shepard, Scott M.;Jessen, Henning J.;Cummins, Christopher C.
低聚磷在生物化学中起着重要的作用，大量的研究都集中在合成天然的低聚磷及其合成类似物上。单磷酸、二磷酸和三磷酸受到了更多的关注，因为它们在生物上存在更高的浓度，而且更容易合成。然而，延伸的寡磷酸盐具有强大的生化作用，从凝血到艾滋病毒耐药性。零星的报道已经慢慢形成了与延伸的寡磷酸盐的合成和研究有关的小众文献，但新发现的兴趣和发展有可能迅速扩大这一领域。在这里，我们报告了目前合成比三磷酸盐更长的寡磷酸盐的方法，并评论了这一领域未来最重要的研究方向。目前的技术水平已经提供了相当稳健的方法来合成核苷5‘-四磷酸和五磷酸以及二核苷5’，5‘-寡磷酸盐。未来的研究应努力将这种合成推向更长的寡磷酸盐，同时开发更稀有形态的合成方法，如3‘-核苷寡磷酸盐、多聚磷酸盐和这些物种的磷酸盐/硫代磷酸盐类似物。
Oligophosphates play essential roles in biochemistry, and considerable research has been directed towards the synthesis of both naturally occurring oligophosphates and their synthetic analogs. Greater attention has been given to mono-, di-, and triphosphates, as these are present in higher concentrations biologically and easier to synthesize. However, extended oligophosphates have potent biochemical roles, ranging from blood coagulation to HIV drug resistance. Sporadic reports have slowly built a niche body of literature related to the synthesis and study of extended oligophosphates, but newfound interests and developments have the potential to rapidly expand this field. Here we report on current methods to synthesize oligophosphates longer than triphosphates and comment on the most important future directions for this area of research. The state of the art has provided fairly robust methods for synthesizing nucleoside 5’-tetra- and pentaphosphates as well as dinucleoside 5’,5’-oligophosphates. Future research should endeavor to push such syntheses to longer oligophosphates while developing synthetic methodologies for rarer morphologies such as 3’-nucleoside oligophosphates, polyphosphates, and phosphonate/thiophosphate analogs of these species.
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影响因子：
2.9
作者：
Choi, Sharon H.;Collins, Julie N. R.;Smith, Stephanie A.;Davis-Harrison, Rebecca L.;Rienstra, Chad M.;Morrissey, James H.
通讯作者：
Morrissey, James H.
DOI：
10.1073/pnas.96.23.13062
发表时间：
1999-11-09
影响因子：
11.1
作者：
Burke, CC;Wildung, MR;Croteau, R
通讯作者：
Croteau, R
影响因子：
3.5
作者：
Shaver, Sammy R;Rideout, Janet L;Pendergast, William;Douglass, James G;Brown, Edward G;Boyer, Jose L;Patel, Roshni I;Redick, Catherine C;Jones, Arthur C;Picher, Maryse;Yerxa, Benjamin R
通讯作者：
Yerxa, Benjamin R
影响因子：
5.2
作者：
Ahmadibeni, Yousef;Parang, Keykavous
通讯作者：
Parang, Keykavous
影响因子：
3.7
作者：
Baker, Catherine J.;Smith, Stephanie A.;Morrissey, James H.
通讯作者：
Morrissey, James H.