Enkleine: an isoquinolone from Enkleia siamensis.
Enkleine: an isoquinolone from Enkleia siamensis.
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Enkleine：来自 Enkleia siamensis 的异喹诺酮。
DOI：
10.1055/s-2006-960214
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发表时间：
1991
期刊：
影响因子：
2.7
通讯作者：
Farnsworth,NR
中科院分区：
文献类型：
--
作者：
Boonyaratanakornkit,L;Che,CT;Cordell,GA;Fong,HH;Farnsworth,NR
Enkleia siamensis Kurz（Thymelaeaceae）是泰国东北部地区常见的攀援灌木。在以前的通信（1），我们已经报道了三个生物活性香豆素，即黄皮苷，daphnoretin，和nordentatin，从根的细胞毒性提取物的分离。对CHC 13级分的进一步研究现已导致分离出两种已知化合物，鉴定为（-）-桉叶结素，chamaejasmin（e），和一种新的异喹诺酮生物碱，enkleine（1），当在KB和P-388细胞培养系统中测试时，它们中的每一种都没有显著的细胞毒性活性。705经鉴定为木脂素（-）-桉叶结素。它的NMR和质谱与桉叶结素的一般结构一致（2，3），但比旋光度表明它与普通的（+）-异构体是对映的。
Enkleia siamensis Kurz (Thymelaeaceae) is a climbing shrub commonly found in the northeastern region of Thailand. In a previous communication (1), we have reported on the isolation of three bioactive coumarins, namely, clausarin, daphnoretin, and nordentatin, from a cytotoxic extract of the roots. Further examination of the CHC13 fraction has now led to the isolation of two known compounds, identified as (—)-eudesmin, chamaej asmin (e), and a new isoquinolone alkaloid, enkleine (1), each of which was devoid of significant cytotoxic activity when tested in the KB and P-388 cell culture systems.The first isolate, mp 104—106 C,[a] 0: 705 was identified as the lignan (—)-eudesmin. Its NMR and mass spectra were consistent with the general struc-ture of eudesmin (2, 3), but the specific optical rotation indicates that it is antipodal to the common (+)-isomer.