Health-related quality of life in type 2 diabetes mellitus patients with different risk for obstructive sleep apnea.
Health-related quality of life in type 2 diabetes mellitus patients with different risk for obstructive sleep apnea.
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DOI：
10.2147/ppa.s165203
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发表时间：
2018
影响因子：
2.2
通讯作者：
Bozic J
中科院分区：
文献类型：
--
作者：
Gabric K;Matetic A;Vilovic M;Ticinovic Kurir T;Rusic D;Galic T;Jonjic I;Bozic J
本研究旨在探讨具有不同阻塞性睡眠呼吸暂停（OSA）风险的2型糖尿病（T2 DM）患者的健康相关生活质量（HRQoL）。这项横断面、基于糖尿病的研究纳入了466例成人T2 DM患者，这些患者于2017年4月至9月定期到斯普利特大学医院糖尿病中心就诊。所有受试者都进行了详细的病史评估和体格检查与人体测量。此外，所有受试者均完成STOP（打鼾、疲劳、观察到的呼吸暂停和高血压）问卷以评估OSA风险，完成埃普沃思嗜睡量表以评估日间嗜睡，完成医学结局研究简表-36（SF-36）工具以评估HRQoL。基于STOP问卷（STOP评分≥2），大多数受试者（N=312，67.0%）代表高风险OSA组。与低危组相比，OSA高危组T2 DM患者的SF-36各维度HRQoL评分均显著降低（P<0.001）。STOP评分与SF-36各维度呈显著负相关（P<0.001）。在多元线性回归分析中，经体重指数、年龄、糖化血红蛋白和T2 DM病程校正后，STOP评分被证实为SF-36所有组分的统计学显著独立预测因子（P<0.001）。我们的研究发现，高比例的T2 DM患者存在OSA的高风险。此外，我们还发现OSA高风险T2 DM患者组在所有SF-36维度上的HRQoL均低于低风险患者组。
Our study primarily aimed to investigate health-related quality of life (HRQoL) in type 2 diabetes mellitus (T2DM) patients with different risk for obstructive sleep apnea (OSA). This cross-sectional, questionnaire-based study included 466 adult patients with T2DM on regular visit to Center for Diabetes of University Hospital of Split from April to September 2017. All subjects underwent detailed anamnestical evaluation and physical examination with anthropometric measurements. Additionally, all subjects completed STOP (Snoring, Tiredness, Observed apnea, and high blood Pressure) questionnaire to assess risk for OSA, Epworth Sleepiness Scale to assess daytime sleepiness, and Medical Outcomes Study Short Form-36 (SF-36) instrument to evaluate HRQoL. Most subjects (N=312, 67.0%) represented high-risk OSA group based on STOP questionnaire (STOP score ≥2). Statistically significantly lower HRQoL scores in all SF-36 dimensions were found in T2DM patients with high risk for OSA compared to low-risk group (P<0.001). STOP score showed statistically significant negative correlation with all SF-36 dimensions (P<0.001). In multiple linear regression analysis, STOP score was confirmed as statistically significant independent predictor for all SF-36 components, adjusted for body mass index, age, glycated hemoglobin, and T2DM duration (P<0.001). Our study found that high proportion of patients with T2DM are at high risk for OSA. Furthermore, we showed that group of T2DM patients with high risk for OSA has lower HRQoL in all SF-36 dimensions compared to low-risk patients.