Motor unit properties of nerve-intact extensor digitorum longus muscle grafts in young and old rats
Motor unit properties of nerve-intact extensor digitorum longus muscle grafts in young and old rats
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DOI：
10.1093/gerona/56.6.b254
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发表时间：
2001-06-01
影响因子：
5.1
通讯作者：
Faulkner, JA
中科院分区：
文献类型：
--
作者：
Cederna, PS;Asato, H;Faulkner, JA
受损的再神经支配被认为是导致老年大鼠与年轻大鼠相比，标准肌肉移植恢复最大力（P-0）的三倍差异的原因。本研究的具体零假设是，与年龄匹配的对照指长伸肌（EDL）相比，神经完整的EDL肌肉移植在年轻和老年大鼠中没有显示出与年龄相关的神经再生损伤的证据。对3月龄和23月龄大鼠进行完整的神经移植，并在术后60天进行评估。与年龄匹配的对照组EDL肌肉相比，年轻大鼠和老年大鼠的神经完整移植物在肌肉质量或运动单位数方面没有差异。两组神经完整移植肌的平均运动单位P-0均显著低于同龄对照肌。这些数据支持我们的假设，即如果轴突在神经内膜环境中再生，没有证据表明肌肉神经再生中存在与年龄相关的损伤。
Impaired reinnervation has been implicated as the cause of the threefold disparity in the recovery of maximum force (P-0)of standard muscle grafts in old compared with young rats. The specific, null hypothesis of this study is that compared with age-matched control extensor digitorum longus (EDL) muscles, nerve-intact EDL muscle grafts in young and old rats show no evidence of an age-related impairment in reinnervation. Nerve-intact grafts were performed in 3-month-old and 23-month-old rats and were evaluated 60 days postoperatively. Compared with age-matched control EDL muscles, nerve-intact grafts in young and old rats showed no difference in muscle mass or motor unit numbers. The mean motor unit P-0 for nerve-intact graft muscles in both age groups was significantly lower than that of age-matched control muscles. These data support our hypothesis that if axons are allowed to regenerate in an endoneurial environment, there is no evidence of an age-related impairment in muscle reinnervation.