Circadian rhythms of locomotor activity in Drosophila
Circadian rhythms of locomotor activity in Drosophila
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DOI：
10.1016/s0376-6357(03)00133-5
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发表时间：
2003-09-29
影响因子：
1.3
通讯作者：
Rouyer, F
中科院分区：
文献类型：
--
作者：
Klarsfeld, A;Leloup, JC;Rouyer, F
果蝇是迄今为止了解生物钟所依赖的复杂生化相互作用的最先进模型。迄今为止，大多数已鉴定的基因都是通过基因筛选分离出来的，利用成年人的运动活动节律作为昼夜节律输出。此外，新技术可以解除特定细胞中基因表达的调节，从而可以分析越来越多的也发挥时钟基因作用的发育基因。然而，昼夜节律生物学的主要挑战之一仍然是正确解释复杂的行为数据并利用它们来推动分子模型。这篇综述试图描述时钟观察者在使用果蝇活动节律来了解昼夜节律功能的多个方面时必须面对的问题。 (C) 2003 Elsevier B.V. 保留所有权利。
Drosophila is by far the most advanced model to understand the complex biochemical interactions upon which circadian clocks rely. Most of the genes that have been characterized so far were isolated through genetic screens using the locomotor activity rhythms of the adults as a circadian output. In addition, new techniques are available to deregulate gene expression in specific cells, allowing to analyze the growing number of developmental genes that also play a role as clock genes. However, one of the major challenges in circadian biology remains to properly interpret complex behavioral data and use them to fuel molecular models. This review tries to describe the problems that clockwatchers have to face when using Drosophila activity rhythms to understand the multiple facets of circadian function. (C) 2003 Elsevier B.V. All rights reserved.