Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection.
Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection.
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DOI：
10.1128/mbio.01267-22
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发表时间：
2022-08-30
期刊：
影响因子：
6.4
通讯作者：
Levy, Bruce D.
中科院分区：
文献类型：
--
作者：
Tavares, Luciana P.;Bruggemann, Thayse R.;Rezende, Rafael M.;Machado, Marina G.;Cagnina, R. Elaine;Shay, Ashley E.;Garcia, Cristiana C.;Nijmeh, Julie;Teixeira, Mauro M.;Levy, Bruce D.
关键词：
甲型流感病毒（IAV）感染是全世界死亡的主要原因。在IAV流行和大流行期间的过高死亡率可归因于继发性细菌感染，特别是由肺炎链球菌引起的肺炎。常驻肺泡巨噬细胞（rAM）是呼吸道感染的早期反应者，协调初始宿主防御反应。组织再生中的Maresin缀合物（MCTR）是最近阐明的由巨噬细胞产生并作用于巨噬细胞的半胱氨酰maresin。MCTR在呼吸道感染反应中的作用仍有待确定。在这里，IAV感染导致rAM数量的短暂减少。再生肺巨噬细胞显示转录改变后21天IAV与继发性肺炎球菌感染的易感性延长。在继发性肺炎球菌感染后48和72小时，IAV后给予MCTR 1至3的混合物或单独给予MCTR 3可降低肺部炎症和细菌负荷。MCTR暴露的rAM增加了肺炎链球菌的迁移和吞噬作用，减少了CXCL 1的分泌，并向几个IAV诱导的肺炎易感基因的基线水平逆转。总之，MCTR反调节rAM中的IAV后变化，以促进细菌宿主防御的快速恢复。
Influenza A virus (IAV) infections are a leading cause of mortality worldwide. Excess mortality during IAV epidemics and pandemics is attributable to secondary bacterial infections, particularly pneumonia caused by Streptococcus pneumoniae. Resident alveolar macrophages (rAMs) are early responders to respiratory infections that coordinate initial host defense responses. Maresin conjugates in tissue regeneration (MCTRs) are recently elucidated cysteinyl maresins that are produced by and act on macrophages. Roles for MCTRs in responses to respiratory infections remain to be determined. Here, IAV infection led to transient decreases in rAM numbers. Repopulated lung macrophages displayed transcriptional alterations 21 days post-IAV with prolonged susceptibility to secondary pneumococcal infection. Administration of a mix of MCTR1 to 3 or MCTR3 alone post-IAV decreased lung inflammation and bacterial load 48 and 72 h after secondary pneumococcal infection. MCTR-exposed rAMs had increased migration and phagocytosis of Streptococcus pneumoniae, reduced secretion of CXCL1, and a reversion toward baseline levels of several IAV-induced pneumonia susceptibility genes. Together, MCTRs counter regulated post-IAV changes in rAMs to promote a rapid return of bacteria host defense.
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影响因子：
8
作者：
Cole SL;Dunning J;Kok WL;Benam KH;Benlahrech A;Repapi E;Martinez FO;Drumright L;Powell TJ;Bennett M;Elderfield R;Thomas C;MOSAIC investigators;Dong T;McCauley J;Liew FY;Taylor S;Zambon M;Barclay W;Cerundolo V;Openshaw PJ;McMichael AJ;Ho LP
通讯作者：
Ho LP
DOI：
10.1086/591708
发表时间：
2008-10-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Morens DM;Taubenberger JK;Fauci AS
通讯作者：
Fauci AS
新型第三Maresin结合物在组织再生中的鉴定和作用：MCTR3。
影响因子：
3.7
作者：
Dalli J;Sanger JM;Rodriguez AR;Chiang N;Spur BW;Serhan CN
通讯作者：
Serhan CN
DOI：
10.1084/jem.20162152
发表时间：
2017-08-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Misharin AV;Morales-Nebreda L;Reyfman PA;Cuda CM;Walter JM;McQuattie-Pimentel AC;Chen CI;Anekalla KR;Joshi N;Williams KJN;Abdala-Valencia H;Yacoub TJ;Chi M;Chiu S;Gonzalez-Gonzalez FJ;Gates K;Lam AP;Nicholson TT;Homan PJ;Soberanes S;Dominguez S;Morgan VK;Saber R;Shaffer A;Hinchcliff M;Marshall SA;Bharat A;Berdnikovs S;Bhorade SM;Bartom ET;Morimoto RI;Balch WE;Sznajder JI;Chandel NS;Mutlu GM;Jain M;Gottardi CJ;Singer BD;Ridge KM;Bagheri N;Shilatifard A;Budinger GRS;Perlman H
通讯作者：
Perlman H
影响因子：
30.5
作者：
Aegerter, Helena;Kulikauskaite, Justina;Wack, Andreas
通讯作者：
Wack, Andreas