Leptospira interrogans and Leptospira peptidoglycans induce the release of tumor necrosis factor alpha from human monocytes
Leptospira interrogans and Leptospira peptidoglycans induce the release of tumor necrosis factor alpha from human monocytes
复制标题
DOI：
10.1016/0378-1097(96)00109-7
复制
发表时间：
1996-05-01
影响因子：
2.1
通讯作者：
Dobrina, A
中科院分区：
文献类型：
--
作者：
Cinco, M;Vecile, E;Dobrina, A
细胞因子肿瘤坏死因子α (TNF α)的血浆浓度升高已在钩端螺旋体病患者中观察到。在这项研究中，我们发现，审问钩端螺旋体的肽聚糖制备，血清哥本哈根，能够诱导外周血单核细胞TNF α的释放。TNF α的诱导以剂量依赖的方式发生，不受内毒素抑制剂polymixin b的影响。这是关于螺旋体肽聚糖诱导TNF α释放的第一篇报道。我们的发现与现有的临床数据一致，并提供了TNF α产生的潜在机制。
Elevated plasma concentrations of the cytokine tumor necrosis factor alpha (TNF alpha) have been observed in patients affected by leptospirosis. In this study we found that a preparation of peptidoglycan of Leptospira interrogans, serovar copenhageni, was able to induce the release of TNF alpha from peripheral blood mononuclear cells. TNF alpha induction occurred in a dose dependent manner and was not affected by the endotoxin inhibitor polymixin B. This is the first report on induction of TNF alpha release by a peptidoglycan of spirochetes. Our findings are consistent with existing clinical data and provide a potential mechanism for TNF alpha production.