Deficiency in short-chain fatty acid β-oxidation affects theta oscillations during sleep
Deficiency in short-chain fatty acid β-oxidation affects theta oscillations during sleep
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DOI：
10.1038/ng1174
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发表时间：
2003-07-01
期刊：
影响因子：
30.8
通讯作者：
Franken, P
中科院分区：
文献类型：
--
作者：
Tafti, M;Petit, B;Franken, P
在啮齿动物中，反常睡眠和探索行为的脑电(EEG)的特征是theta振荡。在这里，我们表明，小鼠的短链酰基辅酶A脱氢酶(由ACADS编码)的缺陷仅在反常睡眠中导致θ频率显着减慢。我们发现Acads在参与theta生成的大脑区域表达，特别是海马体。对Acads基因突变小鼠的基因表达的微阵列分析表明，Glo1(编码乙氧基酶1)基因过度表达，这是一种参与代谢副产物解毒的基因。给突变小鼠注射乙酰化L肉碱(ALCAR)可显著恢复缓慢的theta和Glo1的过度表达。因此，一种被低估的代谢途径，包括脂肪酸β-氧化，也调节睡眠期间的theta振荡。
In rodents, the electroencephalogram (EEG) during paradoxical sleep and exploratory behavior is characterized by theta oscillations. Here we show that a deficiency in short-chain acylcoenzyme A dehydrogenase (encoded by Acads) in mice causes a marked slowing in theta frequency during paradoxical sleep only. We found Acads expression in brain regions involved in theta generation, notably the hippocampus. Microarray analysis of gene expression in mice with mutations in Acads indicates overexpression of Glo1 (encoding glyoxylase 1), a gene involved in the detoxification of metabolic by-products. Administration of acetyl-L-carnitine (ALCAR) to mutant mice significantly recovers slow theta and Glo1 overexpression. Thus, an underappreciated metabolic pathway involving fatty acid beta-oxidation also regulates theta oscillations during sleep.