The Cytoplasmic Tail of MUC1: A Very Busy Place
The Cytoplasmic Tail of MUC1: A Very Busy Place
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DOI：
10.1126/scisignal.127pe35
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发表时间：
2008-07-08
影响因子：
7.3
通讯作者：
Carson, Daniel D.
中科院分区：
文献类型：
--
作者：
Carson, Daniel D.
粘蛋白1（MUC1）在保护上皮细胞免受微生物感染、酶消化和其他刺激物中的作用已经被认识了一段时间。此外，MUC1作为胚胎着床的屏障。MUC1在许多肿瘤中是高度丰富的，其中它在屏障功能中的作用可以用于保护细胞免受宿主免疫系统的影响，而MUC1在某些其他细胞中的丰度较低，例如在滋养层细胞和造血细胞中。MUC1的大部分功能依赖于其大的细胞外胞外域。尽管如此，一系列的研究已经证明了一个令人惊讶的多样性的作用小，高度保守的胞质结构域MUC1在细胞内信号。这些细胞内活动在恶性和非恶性细胞的生理学中具有潜在的作用。
The role of mucin 1 (MUC1) in protecting epithelia from microbial infection, enzymatic digestion, and other irritants has been appreciated for some time. In addition, MUC1 serves as a barrier to embryo implantation. MUC1 is highly abundant in many tumors in which its role in barrier function may serve to protect cells from the host immune system, whereas MUC1 is less abundant in certain other cells-for example, in trophoblasts and hematopoietic cells. Most of the functions of MUC1 depend upon its large, extracellular ectodomain. Nonetheless, a series of studies have demonstrated a surprisingly diverse role for the small, highly conserved cytoplasmic domain of MUC1 in intracellular signaling. These intracellular activities have potential roles in the physiology of both malignant and nonmalignant cells.