The Effects of Cholecystokinin‐like Peptides in Schizophrenics and Normal Human Subjects
The Effects of Cholecystokinin‐like Peptides in Schizophrenics and Normal Human Subjects
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缩胆囊素样肽对精神分裂症患者和正常人的影响
DOI：
10.1111/j.1749-6632.1985.tb29947.x
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发表时间：
1985
影响因子：
5.2
通讯作者：
S. Paul
中科院分区：
文献类型：
--
作者：
D. Hommer;D. Pickar;J. Crawley;H. Weingartner;S. Paul
在一项安慰剂对照、双盲、交叉研究中，8名神经抗精神病药抵抗的精神分裂症患者接受了蓝脂肽(一种类似于CCK的多肽)的治疗。患者每天肌肉注射两次，连续4天，同时维持恒定剂量的氟奋乃静。精神分裂症的阳性或阴性症状在服用安慰剂和蓝景天期间都没有变化。为了进一步确定天青素的作用特征，我们还将其应用于7名正常志愿者，并评估了其对认知和情绪的影响。志愿者肌肉注射天青素(0.3微克/公斤或0.6微克/公斤)或生理盐水安慰剂。Ceruletie对最近或遥远的记忆或注意力没有影响，但更高的剂量确实导致疲劳的显著增加。这些结果表明，尽管CCK样肽没有抗精神病或认知作用，但它们确实能产生轻微的镇静作用。这种镇静作用可能是外周应用CCK引起的“饱腹感”状态的一部分。
Eight neuroleptic-resistant schizophrenic patients were treated with ceruletide, a cholecystokinin-like peptide, in a placebo-controlled, double-blind, crossover study. Ceruletide or placebo was administered intramuscularly twice a day for 4 consecutive days while patients were maintained on a constant dose of fluphenazine. There were no changes in either the positive or negative symptoms of schizophrenia between the periods of placebo and ceruletide administration. To further characterize ceruletide actions we also administered it to seven normal volunteers and evaluated its effects on cognition and mood. Volunteers were administered ceruletide (0.3 micrograms/kg or 0.6 micrograms/kg) or saline placebo intramuscularly. Ceruletide had no effects on recent or remote memory or attention, but the higher dose did cause a significant increase in fatigue. These results suggest that although CCK-like peptides lack antipsychotic or cognitive effects they do induce mild sedation. This sedation may be part of a "satiety-like" state induced by peripheral administration of CCK.