RISK-FACTORS FOR NECROTIZING ENTEROCOLITIS - THE INFLUENCE OF GESTATIONAL-AGE
RISK-FACTORS FOR NECROTIZING ENTEROCOLITIS - THE INFLUENCE OF GESTATIONAL-AGE
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DOI：
10.1136/adc.67.4_spec_no.432
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发表时间：
1992-04-01
影响因子：
4.4
通讯作者：
JEFFERY, H
中科院分区：
文献类型：
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作者：
BEEBY, PJ;JEFFERY, H
经过 7 年的研究，82 名婴儿被确诊患有坏死性小肠结肠炎 (NEC)。对 74 名早产儿进行了病例对照研究，以确定导致 NEC 发生的因素。与胎龄匹配的对照婴儿相比，35 名患有 NEC 且妊娠 30-36 周的婴儿的出生体重百分位数、脐带 pH 值和 1 分钟 Apgar 评分显着较低。相比之下，25-29周组的39名NEC婴儿和对照组之间没有显着差异，只是接受母乳的NEC婴儿较少。这八个足月婴儿似乎都有明显的诱发因素。因此，我们提出了一个模型，其中 NEC 的易感性取决于胎龄。在 25-29 周范围内，所有婴儿都面临着极度早产的风险。在 30-36 周范围内，窒息和生长迟缓的婴儿的风险增加，而足月时似乎需要发生重大诱发事件。
Over a 7 year study period, 82 infants were identified who had necrotising enterocolitis (NEC). A case-control study of the 74 preterm infants was performed to determine those factors which contributed to the development of NEC. The 35 infants with NEC and gestation between 30-36 weeks, when compared with control infants matched for gestational age, had significantly lower birthweight centiles, cord pH, and 1 minute Apgar scores. By contrast, there were no significant differences between the 39 infants with NEC and controls in the 25-29 week group, except that fewer babies with NEC had received breast milk. The eight term babies all appeared to have an obvious predisposing event. We thus propose a model in which susceptibility to NEC is dependent on gestational age. In the 25-29 week range all babies are at risk on the basis of extreme prematurity. In the 30-36 week range asphyxiated and growth retarded babies are at increased risk, while at term a major predisposing event appears to be required.