Is taurine a functional nutrient?
Is taurine a functional nutrient?
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DOI：
10.1097/01.mco.0000247469.26414.55
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发表时间：
2006-11-01
影响因子：
3.1
通讯作者：
Reusens, Brigitte
中科院分区：
文献类型：
--
作者：
Bouckenooghe, Thomas;Remacle, Claude;Reusens, Brigitte
综述目的牛磺酸是一种游离氨基酸，在大多数哺乳动物组织中以毫摩尔浓度存在。哺乳动物能够内源性合成牛磺酸，但某些物种（如人类）更依赖于牛磺酸的饮食来源。越来越多的证据表明，牛磺酸在许多生理过程中起着主导作用，这将在本文中进行综述。最近的研究发现，在许多研究中，包括动物模型和一些临床试验，牛磺酸在人类饮食中的需求证据已经获得。最近和过去的研究表明，牛磺酸可能是一个相关的候选人，作为一种营养补充剂，以防止氧化应激，神经退行性疾病或动脉粥样硬化。牛磺酸在体外实验中表现出了良好的作用，因此临床试验开始研究其对各种疾病的影响。牛磺酸具有多种功能，在许多生理过程中发挥重要作用，如免疫调节，胆盐形成等。最近报道牛磺酸类似物/衍生物对各种疾病具有显著活性。总之，这些观察结果证实了牛磺酸的古老故事。
Purpose of review Taurine, a free amino acid, is found in millimolar concentrations in most mammalian tissues. Mammals are able to synthesize taurine endogenously, but some species such as humans are more dependent on dietary sources of taurine. A growing body of evidence suggests that taurine plays a preponderant role in many physiological processes, which will be summarized in this review.Recent findings Evidence for the requirement of taurine in the human diet has been obtained in many studies involving animal models and a few clinical trials. Recent and past studies suggested that taurine might be a pertinent candidate for use as a nutritional supplement to protect against oxidative stress, neurodegenerative diseases or atherosclerosis. Taurine has demonstrated promising actions in vitro, and as a result clinical trials have begun to investigate its effects on various diseases.Summary Taurine appears to have multiple functions and plays an important role in many physiological processes, such as osmoregulation, immunomodulation and bile salt formation. Taurine analogues/derivatives have recently been reported to have a marked activity on various disorders. Taken together, these observations actualize the old story of taurine.