Tumor size is an independent predictor of lymph node metastasis and survival in early stage endometrioid endometrial cancer
Tumor size is an independent predictor of lymph node metastasis and survival in early stage endometrioid endometrial cancer
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DOI：
10.1007/s00404-014-3609-6
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发表时间：
2015-07-01
影响因子：
2.6
通讯作者：
Moslemi-Kebria, Mehdi
中科院分区：
文献类型：
--
作者：
Mahdi, Haider;Munkarah, Adnan R.;Moslemi-Kebria, Mehdi
Objective(s) To analyze the impact of tumor size (TS) on risk of lymph node metastasis (PLN) and prognosis in endometrioid endometrial cancer grossly confined to the uterus (EEC).Method(s) Patients with EEC grossly confined to the uterus were identified from Surveillance, Epidemiology, and EndResults dataset from 1988 to 2007. Only surgically treated patients were included. TS was analyzed as a continuous and categorical variable (TS 2-5 cm and >5 cm). Multivariable logistic regression and Cox proportional hazards models were used. Result(s) 19,692 patients met the inclusion criteria. In patients with TS 2-5 cm and 11.1 % (195/1,745) with TS > 5 cm. The odds of PLN increased by 14 % for each 1 cm increase in TS after controlling for age, race, depth of myometrial invasion and grade (HR 1.14, 95 % CI 1.10-1.19, p < 0.001). Further, TS was an independent predictor of disease-specific survival (DSS) even after adjusting for age, race, grade, depth of myometrial invasion, lymph node status and adjuvant radiation therapy (HR 1.13 for each 1 cm increment in TS, 95 % 1.08-1.18, p < 0.001). In multivariable analysis, larger TS (>5 cm) was significantly associated with worse DSS (HR 2.09, 95 % 1.31-3.35, p = 0.002); however, there was no significant difference between TS > 2-5 cm versus 5 cm was a predictor of disease-specific survival but no difference in outcome was noted between tumor >2-5 cm and tumor
