ACIDEMIA STIMULATES ACTH, VASOPRESSIN, AND HEART-RATE RESPONSES IN FETAL SHEEP
ACIDEMIA STIMULATES ACTH, VASOPRESSIN, AND HEART-RATE RESPONSES IN FETAL SHEEP
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DOI：
10.1152/ajpregu.1989.257.2.r344
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发表时间：
1989-08-01
影响因子：
--
通讯作者：
CHEN, HG
中科院分区：
文献类型：
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作者：
WOOD, CE;CHEN, HG
促肾上腺皮质激素 (ACTH)、精氨酸加压素 (AVP) 和肾素对出血的反应与出血引起的动脉 pH 值降低高度相关。本研究旨在测试这三个系统对静脉输注 H+ 产生的急性胎儿酸血症的反应。将 HCl 以 0.02 (n = 5)、0.10 (n = 6) 和 0.50 (n = 5) 兆/分钟的速率注入长期插管的胎羊中。以 0.10 和 0.50 meq/min 的速率输注可显着降低胎儿动脉 pH 值并增加动脉 PCO2。以 0.5 meq/min 输注 HCl 期间，胎心率和 ACTH、皮质醇和 AVP 血浆浓度显着增加。任何输注均未显着改变胎儿血浆肾素活性和胎儿动脉血压。这些实验的结果表明，动脉 pH 值降低和/或动脉 PCO2 增加会刺激胎儿 ACTH、AVP 和心率。我们推测这些反应是化学感受器介导的，尽管我们无法根据本研究区分外周和中枢化学感受器的明显相对作用。
Adrenocorticotropic hormone (ACTH), arginine vasopressin (AVP), and renin responses to hemorrhage are highly correlated to the hemorrhage-induced decreases in arterial pH. The present study was designed to test the responses of these three systems to acute fetal acidemia, produced by intravenous infusion of H+. HCl was infused into chronically catheterized fetal sheep at rates of 0.02 (n = 5), 0.10 (n = 6), and 0.50 (n = 5) meg/min. Infusions at rates of 0.10 and 0.50 meq/min significantly decreased fetal arterial pH and increased arterial PCO2. Fetal heart rate and plasma concentrations of ACTH, cortisol, and AVP were significantly increased during infusion of HCl at 0.5 meq/min. Neither fetal plasma renin activity nor fetal arterial blood pressure was significantly altered by any of the infusions. The results of these experiments suggest that fetal ACTH, AVP, and heart rate are stimulated by decreases in arterial pH and/or increases in arterial PCO2. We speculate that these responses are chemoreceptor mediated, although we cannot distinguish the apparent relative roles of peripheral and central chemoreceptors on the basis of the present study.