NBS mediated protocol for the synthesis of N-bridged fused heterocycles in water
NBS mediated protocol for the synthesis of N-bridged fused heterocycles in water
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DOI：
10.1016/j.tetlet.2017.08.017
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发表时间：
2017-09-13
影响因子：
1.8
通讯作者：
Telvekar, Vikas N.
中科院分区：
文献类型：
--
作者：
Bhagat, Saket B.;Telvekar, Vikas N.
已经开发了一种用于从市售起始材料合成N-桥连稠合双环化合物如咪唑并[1，2-a]吡啶、咪唑并[1，2-a]嘧啶和咪唑并[2，1-B]噻唑的简便且环境友好的方案。该反应通过NBS介导的相应芳族酮、1，3-二酮、β-酮酯的α-溴化中间体的原位形成进行，然后用合适的亲核试剂捕获，以在无金属条件下以良好的产率提供这些通用的咪唑稠合双环杂环。(C)2017爱思唯尔有限公司版权所有
A facile and environmental friendly protocol for the synthesis of N-bridged fused bicyclic compounds such as imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrimidines, and imidazo[2,1-b]thiazole, from commercially available starting materials has been developed. The reaction proceeds via NBS mediated in situ formation of alpha-brominated intermediate of corresponding aromatic ketones, 1,3-diketones, beta-keto esters, followed by trapping with suitable nucleophiles to provide these versatile imidazole fused bicyclic heterocycles in good yields under metal-free conditions. (C) 2017 Elsevier Ltd. All rights reserved.