EFFECTS OF PLACENTOPHAGY ON SERUM PROLACTIN AND PROGESTERONE CONCENTRATIONS IN RATS AFTER PARTURITION OR SUPER-OVULATION
EFFECTS OF PLACENTOPHAGY ON SERUM PROLACTIN AND PROGESTERONE CONCENTRATIONS IN RATS AFTER PARTURITION OR SUPER-OVULATION
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DOI：
10.1530/jrf.0.0600273
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发表时间：
1980-01-01
期刊：
影响因子：
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通讯作者：
FRIESEN, HG
中科院分区：
文献类型：
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作者：
BLANK, MS;FRIESEN, HG
与不吃胎盘的大鼠相比，产后第1天允许吃胎盘的大鼠血清催乳素（PRL）浓度升高，产后第6天和第8天血清孕酮(P)浓度降低。妊娠母马血清促性腺激素诱导超排卵的大鼠，在连续饲喂2 g大鼠胎盘2 d后，血清PL和P值分别在第3天和第5天显著（P < 0.05）升高。饲喂每只大鼠4 g胎盘/d显著降低第5天血清P （P < 0.02）。雌激素注射或牛胎盘或人胎盘饮食没有影响。大鼠胎盘的石油醚提取物有机相（2 g当量/天）在第5天降低了P的外周浓度，但其他提取物无效。显然，大鼠胎盘含有口服活性物质，可以改变血液中垂体和卵巢激素的水平。
In rats that were allowed to eat the placentae after parturition concentrations of serum prolactin [PRL] were elevated on day 1 but concentrations of serum progesterone [P] were depressed on days 6 and 8 post partum when compared to those of rats prevented from eating the placentae. In rats treated with pregnant mare serum gonadotropin to induce superovulation serum PL and P values were significantly (P < 0.05) elevated on days 3 and 5, respectively, after being fed 2 g rat placenta/day for 2 days. Feeding each rat 4 g placenta/day significantly (P < 0.02) lowered serum P on day 5. Estrogen injections or bovine or human placenta in the diet had no effect. The organic phase of a petroleum ether extract of rat placenta (2 g-equivalents/day) lowered peripheral concentrations of P on day 5, but other extracts were ineffective. Evidently rat placenta contains orally-active substance(s) which modify blood levels of pituitary and ovarian hormones.