Liquid biopsy approach in the management of prostate cancer.

Liquid biopsy approach in the management of prostate cancer.
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DOI:
10.1016/j.trsl.2018.05.004
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发表时间:
2018-11
期刊:
Translational research : the journal of laboratory and clinical medicine
影响因子:
--
通讯作者:
Kohli M
Kohli M
中科院分区:
其他
文献类型:
--
作者:
Riaz IB;Wang L;Kohli M

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Liquid biopsies examine tumor cells or tumor genomic content in circulating fluids. In advanced prostate cancer which metastasizes frequently to the bone, it is difficult to evaluate underlying and evolving genomic heterogeneity of skeletal metastases for effecting clinical care for which reason liquid biopsies offer an alternate approach. In this review, we will summarize the current state of a wide variety of liquid biopsy-based biomarker assays currently being investigated and developed for managing prostate cancer. We will also highlight technical and clinical challenges and opportunities for translating liquid biopsies into clinical applications.
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