DIFFERENT GAMMA-DELTA-T-CELL RECEPTORS ARE EXPRESSED ON THYMOCYTES AT DIFFERENT STAGES OF DEVELOPMENT
DIFFERENT GAMMA-DELTA-T-CELL RECEPTORS ARE EXPRESSED ON THYMOCYTES AT DIFFERENT STAGES OF DEVELOPMENT
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DOI：
10.1073/pnas.86.2.631
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发表时间：
1989-01-01
影响因子：
11.1
通讯作者：
TONEGAWA, S
中科院分区：
文献类型：
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作者：
ITO, K;BONNEVILLE, M;TONEGAWA, S
我们分析了鼠γ的结构多样性。在CD 4-CD 8-胸腺细胞群和TCR γ上表达的δ T细胞受体（TCR）异二聚体。三角洲-表达源自胎儿、新生和成年小鼠胸腺细胞的杂交瘤。我们发现来源于不同出生前和出生后年龄的小鼠的CD 4-CD 8-胸腺细胞优先表达γ。由γ的不同子集编码的δ TCR。和δ基因片段这种γ的年龄依赖性差异表达δ的胸腺细胞上的TCR似乎部分通过重排γ的特异性控制来实现。在转录和/或RNA稳定性水平上起作用的基因。我们讨论了这些发现的影响方面的识别作用的γ。delta.TCR.
We have analyzed the structural diversity of the murine .gamma..delta.T-cell receptor (TCR) heterodimer expressed on CD4- CD8- thymocyte populations and on TCR .gamma..delta.-expressing hybridomas derived from thymocytes of fetal, newborn, and adult mice. We found that CD4- CD8- thymocytes derived from mice of different pre- and postnatal age preferentially express a .gamma..delta.TCR encoded by different subsets of .gamma. and .delta. gene segments. This age-dependent differential expression of .gamma..delta. TCR on thymocytes seems to be accomplished in part by a specific control of rearranged .gamma. genes operating at the level of transcription and/or RNA stability. We discuss the implications of these findings with respect to the recognition roles of the .gamma..delta.TCR.