PHYSICAL-ACTIVITY AND IMMUNE FUNCTION IN ELDERLY WOMEN
PHYSICAL-ACTIVITY AND IMMUNE FUNCTION IN ELDERLY WOMEN
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DOI：
10.1249/00005768-199307000-00011
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发表时间：
1993-07-01
期刊：
影响因子：
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通讯作者：
NEHLSENCANNARELLA, SL
中科院分区：
文献类型：
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作者：
NIEMAN, DC;HENSON, DA;NEHLSENCANNARELLA, SL
采用随机对照实验设计，随访12周，研究老年妇女心肺运动、免疫功能和上呼吸道感染（URTI）之间的关系。32个久坐不动年龄在67-85岁之间的老年白人妇女，符合特定的选择标准，被随机分为步行组或健身组：30人完成了研究。十二个条件很好的老年妇女。65-84岁。在基线时招募积极参加耐力比赛的人进行横断面比较。干预组运动30-40 min，5 d.wk-1，共12 wk，步行组训练60%的心率储备，健身操组进行温和的运动范围和灵活性运动，使心率接近静息水平。在基线时，高度适应的受试者表现出上级的NK（119 +/- 13 vs 77 +/- 8裂解单位，P < 0.01）和T（33.3 +/- 4.9 vs 21.4 +/- 2.1 cpm x 10（-3），使用PHA。P < 0.05）细胞功能。尽管淋巴细胞亚群的循环水平没有差异。12周的适度心肺运动使久坐受试者的最大摄氧量提高了12.6%，但没有导致NK细胞活性或T细胞功能的任何改善。在为期12周的研究中，高度调节组的URTI发病率最低，健身操对照组最高，步行者处于中间位置（卡方= 6.36，P = 0.042）。总之，在这项研究中，与久坐的老年妇女相比，高度调节的老年妇女具有上级NK和T细胞功能。12周的适度心肺运动。然而，与以前久坐的老年妇女免疫功能的改善无关。
The relationship between cardiorespiratory exercise, immune function, and upper respiratory tract infection (URTI) was studied in elderly women utilizing a randomized controlled experimental design with a follow-up of 12 wk. Thirty-two sedentary. elderly Caucasian women, 67-85 vr of age, who met specific selection criteria, were randomized to either a walking or calisthenic group: 30 completed the study. Twelve highly conditioned elderly women. 65-84 yr of age. who were active in endurance competitions, were recruited at baseline for cross-sectional comparisons. Intervention groups exercised 30-40 min, 5 d.wk-1, for 12 wk, with the walking group training at 60% heart rate reserve and the calisthenic group engaging in mild range-of-motion and flexibility movements that kept their heart rates close to resting levels. At baseline, the highly conditioned subjects exhibited superior NK (119 +/- 13 vs 77 +/- 8 lytic units, P < 0.01) and T (33.3 +/- 4.9 vs 21.4 +/- 2.1 cpm x 10(-3) using PHA. P < 0.05) cell function. despite no differences in circulating levels of lymphocyte subpopulations. Twelve weeks of moderate cardiorespiratory exercise improved the VO2max of the sedentary subjects 12.6%, but did not result in any improvement in NK cell activity or T cell function. Incidence of URTI was lowest in the highly conditioned group and highest in the calisthenic control group during the 12-wk study, with the walkers in an intermediate position (chi-square = 6.36, P = 0.042). In conclusion, the highly conditioned elderly women in this study had superior NK and T cell function when compared with their sedentary counterparts. Twelve weeks of moderate cardiorespiratory exercise. however, was not associated with an improvement in immune function in previously sedentary elderly women.