Structural and functional recovery from early monocular deprivation in adult rats
Structural and functional recovery from early monocular deprivation in adult rats
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DOI：
10.1073/pnas.0602657103
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发表时间：
2006-05-30
影响因子：
11.1
通讯作者：
Maffei, Lamberto
中科院分区：
文献类型：
--
作者：
Pizzorusso, Tommaso;Medini, Paolo;Maffei, Lamberto
成年动物在发育过程中因视觉体验异常而导致的视觉缺陷是难以恢复的。用软骨素酶ABC从成熟的细胞外基质中去除硫酸软骨素蛋白聚糖可促进成人视觉皮层的可塑性。我们测试了对成年大鼠进行软骨素酶ABC治疗是否有助于从单眼剥夺的关键时期开始的一段时间的影响中恢复解剖学、功能和行为。我们发现，软骨素酶ABC治疗结合反向眼睑缝合可使成年大鼠的眼优势、视力和树突棘密度完全恢复。因此，细胞外基质的操作可用于促进成人皮层的功能恢复。
Visual deficits caused by abnormal visual experience during development are hard to recover in adult animals. Removal of chondroitin sulfate proteoglycans from the mature extracellular matrix with chondroitinase ABC promotes plasticity in the adult visual cortex. We tested whether chondroitinase ABC treatment of adult rats facilitates anatomical, functional, and behavioral recovery from the effects of a period of monocular deprivation initiated during the critical period for monocular deprivation. We found that chondroitinase ABC treatment coupled with reverse lid-suturing causes a complete recovery of ocular dominance, visual acuity, and dendritic spine density in adult rats. Thus, manipulations of the extracellular matrix can be used to promote functional recovery in the adult cortex.