SERUM DEOXYRIBONUCLEASE-I AND CLINICAL ACTIVITY IN SYSTEMIC LUPUS-ERYTHEMATOSUS
SERUM DEOXYRIBONUCLEASE-I AND CLINICAL ACTIVITY IN SYSTEMIC LUPUS-ERYTHEMATOSUS
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DOI：
10.1007/bf00541153
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发表时间：
1981-01-01
影响因子：
4
通讯作者：
TAN, EM
中科院分区：
文献类型：
--
作者：
CHITRABAMRUNG, S;RUBIN, RL;TAN, EM
系统性红斑狼疮（SLE）患者血清脱氧核糖核酸酶Ⅰ（DNase Ⅰ）活性明显低于健康人、类风湿关节炎和硬皮病患者（P<0.001）。SLE血清中DNase I活性的降低不是由于各种自身抗体或热不稳定DNase I抑制剂的作用。血清DNA酶I活性与活动性SLE的关系。活动性狼疮肾炎患者的酶活性水平最低。
Serum deoxyribonuclease I (DNase I) activity in systemic lupus erythematosus (SLE) patients was shown to be lower than that of healthy laboratory personnel, rheumatoid arthritis, and scleroderma patients (P<0.001). The decrease in DNase I activity in SLE sera was not due to the effect of various autoantibodies or to heat labile DNase I inhibitor. A relationship between serum DNase I activity and active SLE was demonstrated. Patients with active lupus nephritis had the lowest levels of enzymatic activity.