Reduction of radiation accumulation in salivary glands through oral vitamin C during 68Ga-PSMA-11 total-body dynamic PET/CT imaging
Reduction of radiation accumulation in salivary glands through oral vitamin C during 68Ga-PSMA-11 total-body dynamic PET/CT imaging
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DOI：
10.1097/mnm.0000000000001506
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发表时间：
2022-02-01
影响因子：
1.5
通讯作者：
Shi, Hongcheng
中科院分区：
文献类型：
--
作者：
Yu, Haojun;Lv, Jing;Shi, Hongcheng
目的 本研究探讨了使用 Ga-68 标记的前列腺特异性膜抗原 (Ga-68-PSMA-11) 进行全身动态 PET/计算机断层扫描 (CT) 成像时，口服维生素 C 在减少唾液腺辐射积累方面的效用。方法 我们招募了 31 名接受 Ga-68-PSMA-11 全身动态 PET/CT 成像的患者，其中 11 名患者在开始动态 PET 采集后 30 分钟口服维生素 C，而其他患者则没有。 PET 采集完成后，感兴趣的体积会自动在腮腺和下颌下唾液腺上进行分割。比较试验组和对照组之间采集 30-60 分钟期间的标准摄取值 (SUV)（平均值）及其斜率。结果试验组左右腮腺和颌下腺的SUV平均值分别为15.37±3.07、15.03±2.64、14.92±4.38和15.38±4.18。对照组的相应值为19.37+/-3.82、20.08+/-3.55、22.61+/-5.62和22.73+/-5.90。试验组中左、右腮腺和下颌下腺采集 30-60 分钟期间的 SUV 平均斜率分别为 0.63 +/- 0.13、0.64 +/- 0.14、0.56 +/- 0.25 和 0.62 +/- 0.26。对照组的相应值为0.84+/-0.21、0.84+/-0.17、1.01+/-0.34和1.02+/-0.37。结论 口服维生素C可减少Ga-68-PSMA-11全身动态PET/CT显像时唾液腺辐射累积。
Objective This study explored the utility of oral vitamin C in reducing radiation accumulation in the salivary glands during total-body dynamic PET/computed tomography (CT) imaging with Ga-68 labeled Prostate-specific membrane antigen (Ga-68-PSMA-11). Methods We enrolled 31 patients who underwent total-body dynamic PET/CT imaging with Ga-68-PSMA-11, of which 11 were given oral vitamin C 30 min after starting the dynamic PET acquisition, whereas the others did not. The volume of interest was automatically segmented on the parotid and submandibular salivary glands once the PET acquisition was completed. The standard uptake value (SUV)(mean) and its slope during 30-60 min of the acquisition were compared between the trial and control groups. Results The SUVmean of the left and right parotid and submandibular glands in the trial group were 15.37 +/- 3.07, 15.03 +/- 2.64, 14.92 +/- 4.38 and 15.38 +/- 4.18, respectively. The respective values of the control group were 19.37 +/- 3.82, 20.08 +/- 3.55, 22.61 +/- 5.62 and 22.73 +/- 5.90. The SUVmean slope during 30-60 min of acquisition for the left and right parotid and submandibular glands in the trial group were 0.63 +/- 0.13, 0.64 +/- 0.14, 0.56 +/- 0.25 and 0.62 +/- 0.26, respectively. The respective values of the control group were 0.84 +/- 0.21, 0.84 +/- 0.17, 1.01 +/- 0.34 and 1.02 +/- 0.37. Conclusion Oral vitamin C could reduce the accumulation of radiation in the salivary glands during Ga-68-PSMA-11 total-body dynamic PET/CT imaging.