A novel Borrelia species, intermediate between Lyme disease and relapsing fever groups, in neotropical passerine-associated ticks
A novel Borrelia species, intermediate between Lyme disease and relapsing fever groups, in neotropical passerine-associated ticks
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DOI：
10.1038/s41598-020-66828-7
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发表时间：
2020-06-30
影响因子：
4.6
通讯作者：
Duron, Olivier
中科院分区：
文献类型：
--
作者：
Binetruy, Florian;Garnier, Stephane;Duron, Olivier
莱姆病（LD）和复发热（RF）是由疏螺旋体属的细菌引起的媒介传播疾病。在这里，我们报告了广泛感染的非描述的疏螺旋体物种的雀形目相关蜱在热带雨林的法属圭亚那，南美洲。这种新的疏螺旋体物种在两种蜱物种中常见，长吻钝眼蜱和钝眼钝眼蜱。它们以各种新热带哺乳动物和鸟类为食，包括迁移到北美的迁徙物种。新的疏螺旋体属物种不同于LD和RF物种，并且与最近描述的爬行动物和针鼹鼠相关的疏螺旋体组更密切相关。基因组测序表明，这种新的疏螺旋体属物种具有一个相对较小的基因组，由一个0.9 Mb的大染色体和一个额外的0.3 Mb分散在质粒上。它具有RF样基因组组织，但具有LD和RF特异性基因的独特混合物，包括RF疏螺旋体用于多相抗原转换系统的基因和许多用于LD诊断的免疫反应蛋白基因。总的来说，我们的数据表明，这种新的疏螺旋体是LD和RF物种之间的中间类群，可能会影响一个大的宿主谱，包括美洲哺乳动物。建议将该物种命名为“马库里疏螺旋体”。
Lyme disease (LD) and relapsing fevers (RF) are vector-borne diseases caused by bacteria of the Borrelia genus. Here, we report on the widespread infection by a non-described Borrelia species in passerine-associated ticks in tropical rainforests of French Guiana, South America. This novel Borrelia species is common in two tick species, Amblyomma longirostre and A. geayi, which feed on a broad variety of neotropical mammal and bird species, including migratory species moving to North America. The novel Borrelia species is divergent from the LD and RF species, and is more closely related to the reptile- and echidna-associated Borrelia group that was recently described. Genome sequencing showed that this novel Borrelia sp. has a relatively small genome consisting of a 0.9-Mb-large chromosome and an additional 0.3Mb dispersed on plasmids. It harbors an RF-like genomic organization but with a unique mixture of LD- and RF-specific genes, including genes used by RF Borrelia for the multiphasic antigen-switching system and a number of immune-reactive protein genes used for the diagnosis of LD. Overall, our data indicate that this novel Borrelia is an intermediate taxon between the LD and RF species that may impact a large host spectrum, including American mammals. The designation "Candidatus Borrelia mahuryensis" is proposed for this species.