A Randomized, Pilot Study to Assess the Efficacy and Safety of Curcumin in Patients with Active Rheumatoid Arthritis
A Randomized, Pilot Study to Assess the Efficacy and Safety of Curcumin in Patients with Active Rheumatoid Arthritis
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DOI：
10.1002/ptr.4639
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发表时间：
2012-11-01
影响因子：
7.2
通讯作者：
Goel, Ajay
中科院分区：
文献类型：
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作者：
Chandran, Binu;Goel, Ajay
众所周知，姜黄素具有有效的抗炎和抗关节炎的特性。本初步临床研究评估了姜黄素单用和双氯芬酸钠联用治疗活动性类风湿关节炎（RA）的安全性和有效性。45名确诊为类风湿性关节炎的患者被随机分为三组，分别接受姜黄素（500毫克）和双氯芬酸钠（50毫克）单独或联合治疗。主要终点是疾病活动评分（DAS） 28的降低。次要终点包括美国风湿病学会（ACR）减轻压痛和关节肿胀评分的标准。三个治疗组患者的DAS评分均有统计学意义的变化。有趣的是，姜黄素组在总体DAS和ACR评分（ACR 20、50和70）方面的改善百分比最高，这些评分明显好于双氯芬酸钠组。更重要的是，姜黄素治疗被发现是安全的，与任何不良事件无关。我们的研究为姜黄素治疗活动性RA患者的安全性和优越性提供了第一个证据，并强调了未来需要进行大规模试验来验证这些发现在RA和其他关节炎患者中的应用。版权所有：John Wiley & Sons， Ltd。
Curcumin is known to possess potent antiinflammatory and antiarthritic properties. This pilot clinical study evaluated the safety and effectiveness of curcumin alone, and in combination with diclofenac sodium in patients with active rheumatoid arthritis (RA). Forty-five patients diagnosed with RA were randomized into three groups with patients receiving curcumin (500 mg) and diclofenac sodium (50 mg) alone or their combination. The primary endpoints were reduction in Disease Activity Score (DAS) 28. The secondary endpoints included American College of Rheumatology (ACR) criteria for reduction in tenderness and swelling of joint scores. Patients in all three treatment groups showed statistically significant changes in their DAS scores. Interestingly, the curcumin group showed the highest percentage of improvement in overall DAS and ACR scores (ACR 20, 50 and 70) and these scores were significantly better than the patients in the diclofenac sodium group. More importantly, curcumin treatment was found to be safe and did not relate with any adverse events. Our study provides the first evidence for the safety and superiority of curcumin treatment in patients with active RA, and highlights the need for future large-scale trials to validate these findings in patients with RA and other arthritic conditions. Copyright (c) 2012 John Wiley & Sons, Ltd.