IL-15-PI3K-AKT-mTOR: A Critical Pathway in the Life Journey of Natural Killer Cells.
IL-15-PI3K-AKT-mTOR: A Critical Pathway in the Life Journey of Natural Killer Cells.
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DOI：
10.3389/fimmu.2015.00355
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发表时间：
2015
影响因子：
7.3
通讯作者：
Lee SH
中科院分区：
文献类型：
--
作者：
Ali AK;Nandagopal N;Lee SH
在众多调节自然杀伤 (NK) 细胞功能的细胞因子中，白介素 15 (IL-15) 发挥着广泛的作用，从发育和稳态到感染过程中成熟 NK 细胞的激活。 IL-15 用于促进 NK 细胞增殖和抗肿瘤反应的临床试验进一步凸显了其重要性。在 IL-15 受体与其配体结合触发的信号转导途径中，PI3K-AKT-mTOR 途径似乎对于 IL-15 介导的 NK 细胞激活至关重要，因此负责有效的抗病毒和抗肿瘤反应。本综述概述了 IL-15 在 NK 细胞生命历程的多个阶段中的作用。了解 IL-15 传递关键信号以产生具有有效效应功能的 NK 细胞的途径，结合已建立的离体 NK 细胞扩增方案，无疑将为针对感染和癌症的免疫调节治疗应用开辟新途径。
Among numerous cytokines modulating natural killer (NK) cell function, interleukin 15 (IL-15) exerts a broad range of effect from development and homeostasis, to activation of mature NK cells during infection. Its significance is further highlighted by clinical trials in which IL-15 is being used to boost the proliferation and anti-tumor response of NK cells. Among the signal transduction pathways triggered by the engagement of IL-15 receptor with its ligand, the PI3K–AKT–mTOR pathway seems to be critical for the IL-15-mediated activation of NK cells, therefore being responsible for efficient anti-viral and anti-tumor responses. This review provides an overview of the role of IL-15 at multiple stages of NK cell life journey. Understanding the pathway by which IL-15 conveys critical signals for the generation of NK cells with efficient effector functions, in combination with established protocols for NK cell expansion ex vivo, will undoubtedly open new avenues for therapeutic applications for immunomodulation against infections and cancers.