CHRONIC NEUROLOGICAL SEQUELAE OF ACUTE ORGANO-PHOSPHATE PESTICIDE POISONING
CHRONIC NEUROLOGICAL SEQUELAE OF ACUTE ORGANO-PHOSPHATE PESTICIDE POISONING
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DOI：
10.1080/00039896.1988.9934372
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发表时间：
1988-01-01
期刊：
影响因子：
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通讯作者：
BURCAR, PJ
中科院分区：
文献类型：
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作者：
SAVAGE, EP;KEEFE, TJ;BURCAR, PJ
为了评估有机磷农药中毒的潜在神经影响，本表皮研究检查了100对配对的个人与以前的急性有机磷农药中毒和非中毒的控制。在听力测试、眼科测试、脑电图或临床血清和血液化学评估中，中毒受试者和对照者之间没有显著差异。在神经系统检查的50多个分数中，只有记忆、抽象和情绪的测量以及运动反射的一个测试在病例中表现出异常。在神经心理学测试中，这两个群体之间的差异更为明显。这些差异发生在各种各样的能力测试中，包括智力功能，学术技能，抽象和灵活的思维，以及简单的运动技能。Halstead-Reitan综合评分在脑损伤或功能障碍个体特征范围内的病例是对照组的两倍（24 vs. 12）。明尼苏达多相人格调查表和患者和亲属对患者功能调查表的评估结果也显示，中毒受试者的痛苦和残疾投诉更大。
To evaluate the latent neurological effects of organophosphate pesticide poisoning, this epidermiologic study examined 100 matched-pairs of individuals with previous acute organophosphate pesticide poisoning and nonpoisoned controls. No significant difference between poisoned subjects and controls was found on audiometric tests, ophthalmic tests, electroecephalograms, or the clinical serum and blood chemistry evaluations. Of the more than 50 scores from the neurological examination, abnormalities were demonstrated among the cases only on measures of memory, abstraction, and mood, and on one test of motor reflexes. Differences between the two cohorts were much more apparent in the neuropsychological tests. The differences occurred on tests of widely varying abilities including intellectual functioning, academic skills, abstraction and flexibility of thinking, and simple motor skills. Twice as many cases as controls (24 vs. 12) had Halstead-Reitan Battery summary scores in the range characteristic of individuals with cerebral damage or dysfunction. Results from the Minnesota Multiphasic Personality Inventory and the Patient''s and Relative''s Assessment of Patient Functioning Inventories also revealed greater distress and complaints of disability for the poisoned subjects.