Haemodynamics, plasma noradrenaline and plasma renin in hypertensive and normotensive teenagers.
Haemodynamics, plasma noradrenaline and plasma renin in hypertensive and normotensive teenagers.
复制标题
高血压和血压正常青少年的血流动力学、血浆去甲肾上腺素和血浆肾素。
DOI：
10.1042/cs0610169
复制
发表时间：
1981
期刊：
影响因子：
6
通讯作者：
H. Valkenburg
中科院分区：
文献类型：
--
作者：
A. Hofman;J. Roelandt;F. Boomsma;M. Schalekamp;H. Valkenburg
1.对41例年龄在10-19岁的高血压患者进行了血浆去甲肾上腺素、血浆肾素活性和非活性血浆肾素、心脏指数和外周血管总阻力的测定，并与年龄、性别和体重指数相匹配的41名正常血压对照组进行了至少2年的随访。2.与对照组比较，高血压患者的平均心脏指数(3.63+/-SD 0.83比4.00+/-0.89升/分-1米-2)、平均外周阻力(26.8+/-5.7比22.8+/-5.5单位)和血浆去甲肾上腺素水平(336+/-146比281+/-126 pg/ml)明显升高。3.肾素活性增高的初发高血压患者血浆去甲肾上腺素平均浓度高于肾素浓度正常者(442+/-70pg/ml比324+/-100pg/ml)。4.血压正常者血浆肾素活性浓度与左心室质量的加权标准化回归系数为0.77。5.这些发现与青年高血压患者存在的高动力时相不一致，提示交感神经过度活动可能通过外周血管阻力增加而与早期高血压有关。
1. Plasma noradrenaline, active and inactive plasma renin, cardiac index and total peripheral vascular resistance were studied in 41 subjects, initially aged 10-19 years, who were followed up for at least 2 years after a blood pressure reading of 140 and/or 90 mmHg or more (initial hypertensives) and in 41 normotensive control subjects selected from the same population and matched for age, sex and body-mass index. 2. The initial hypertensive subjects had a lower mean cardiac index (3.63 +/- SD 0.83 vs 4.00 +/- 0.89 litre min-1 m-2), a higher mean total peripheral resistance (26.8 +/- 5.7 vs 22.8 +/- 5.5 peripheral resistance (26.8 +/- 5.7 vs 22.8 +/- 5.5 units) and a higher mean plasma noradrenaline units) and a higher mean plasma noradrenaline concentration (336 +/- 146 vs 281 +/- 126 pg/ml) than the control subjects. 3. Mean plasma noradrenaline concentration was higher in initial hypertensive subjects with a high active renin concentration than in those with a normal renin concentration (442 +/- 70 vs 324 +/- 100 pg/ml). 4. A weight-adjusted standardized regression coefficient of 0.77 between active plasma renin concentration and left ventricular mass was found in normotensive control subjects. 5. These findings are at variance with the existence of a hyperkinetic phase in young hypertensive subjects and suggest that sympathetic overactivity may be related to early essential hypertension through increase of peripheral vascular resistance.