Attitudes toward preimplantation genetic testing for aneuploidy among patients with recurrent pregnancy loss in Japan
Attitudes toward preimplantation genetic testing for aneuploidy among patients with recurrent pregnancy loss in Japan
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日本复发性流产患者对非整倍体植入前基因检测的态度
DOI：
10.1111/jog.14212
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发表时间：
2020
影响因子：
1.6
通讯作者：
Sato Takeshi
中科院分区：
文献类型：
--
作者：
Takeda Eri;Sugiura‐Ogasawara Mayumi;Ebara Takeshi;Kitaori Tamao;Goto Shinobu;Yoshihara Hiroyuki;Sato Takeshi
目的了解复发性妊娠丢失(RPL)患者对植入前非整倍体基因检测(PGT-A)的态度，因为尽管鲜有证据表明它是否能提高活产率和防止流产，但该技术已在全球范围内开展。方法采用问卷调查法，对2014年11月至2019年1月间386例RPL患者对PGT-A的态度、对PGT-A的需求及相关因素进行了调查。对于需要PGT-A的原因，42.3%的人认为这会确保活产，并通过完整的病例分析表明，患者希望将PGT-A作为一种活产方式的意愿受其体外受精-ET史(调整后的优势比2.7，95%可信区间1.2~7.2)和是否了解PGT-A(2.4，1.1~5.3)的影响。家庭总收入较高(3.5，1.2~10.1)和有IVF-ET史(4.6，2.0~10.3)的患者倾向于将PGT-A作为避免流产的一种手段。结论大多数患者对PGT-A没有意见或对PGT-A了解较少，更多的患者自评为知道PGT-A或接受过IVF-ET。在就PGT-A作出决定之前，来自不同于进行PGT-A的设施的准确和最新信息是必要的。
AimTo examine attitudes toward preimplantation genetic testing for aneuploidy (PGT‐A) in patients with recurrent pregnancy loss (RPL) because it has been performed worldwide in spite of little evidence regarding whether it can improve the live birth rate and prevent miscarriage. There has been no study to examine attitudes toward PGT‐A in patients with RPL.MethodsWe conducted a cross‐sectional study that used a questionnaire to examine attitudes toward PGT‐A, the desire for PGT‐A and the factors associated with this desire in 386 patients with RPL between November 2014 and January 2019.ResultsOverall, 25.1% of patients desired PGT‐A and 35.2% answered that they knew about it. Regarding the reasons for wanting PGT‐A, 42.3% thought that it would insure a live birth and with complete case analysis, showed that the patients' wish for PGT‐A as a means of giving live birth was affected by their IVF‐ET history (adjusted odds ratio 2.7, 95% CI 1.2–7.2) and whether they had any knowledge of PGT‐A (2.4, 1.1–5.3). Those with a higher total family income (3.5, 1.2–10.1) and a previous IVF‐ET (4.6, 2.0–10.3) tended to want PGT‐A as a means of avoiding miscarriage.ConclusionThe majority had no opinion or a poor knowledge of PGT‐A. More patients who self‐assessed as knowing about PGT‐A or who had undergone IVF‐ET had the above type of misunderstanding. Accurate and up‐to‐date information from facilities different from those in which PGT‐A is performed is necessary before reaching a decision on PGT‐A.