Comparative analysis of malaria parasite density using actual and assumed white blood cell counts
Comparative analysis of malaria parasite density using actual and assumed white blood cell counts
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DOI：
10.1179/146532807x170547
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发表时间：
2007-03-01
影响因子：
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通讯作者：
Uko, Emmanuel Kufre
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文献类型：
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作者：
Jeremiah, Zaccheaus Awortu;Uko, Emmanuel Kufre
目的：为了比较疟疾寄生虫密度，使用个体儿童的白色细胞计数（WBC）与8.0 x 10（9）/L的标准WBC计数计算。方法：在一项横断面研究中，估计了240名1-8岁健康尼日利亚儿童的疟疾WBC和疟疾寄生虫密度的患病率。240名儿童中，疟疾75人（31.25%），恶性疟原虫69人（28.75%），其他9人（3.75%）。平均（SD）WBC计数为5.1（2.0）x 10（9）/L。平均WBC计数存在与年龄相关的显著差异（t = 2.000，p < 0.05），5岁以下组的值[5.6（2.0）x 10（9）/L]高于≥ 5岁组[5.0（1.8）x 10（9）/L]。在性别和疟疾感染方面没有观察到显著差异。使用假定值8.0 x 109/L [1936]获得的恶性疟原虫平均（SD）寄生虫密度（1119.5）]显著高于使用个体WBC计数估计的寄生虫密度[1140结论：以8.0 × 10（9）/L的假定计数估算寄生虫密度可能会导致对寄生虫负荷的高估。当需要寄生虫密度时，应始终估计个体患者的WBC。
Aim: To compare malaria parasite densities, calculated using the white cell counts (WBC) of individual children with a standard WBC count of 8.0 x 10(9)/L.Methods: In a cross-sectional study, the prevalence of malaria WBCs and malaria parasite densities were estimated in 240 healthy Nigerian children aged 1-8 years.Results: Of 240 children, 75 (31.25%) were infected with malaria, 69 (28.75%) with P. falciparum and 9 (3.75%) with other species. The mean (SD) WBC count was 5.1 (2.0) x 10(9)/L. There was an age-related significant difference in the mean WBC counts (t = 2.000, p < 0.05), with values higher in the under-5s [5.6 (2.0) x 10(9)/L] than in the >= 5-years group [5.0 (1.8) x 10(9)/L]. No significant difference was observed with regard to gender and malaria infection. The mean (SD) parasite densities of P. falciparum obtained using the assumed value of 8.0 x 109/L [1936 (1119.5)] was significantly higher than the parasite densities estimated using the individual WBC counts [1140 (862.8) for P. falciparum] (p < 0.0001).Conclusion: Parasite density estimation using the assumed count of 8.0 x 10(9)/L might result in over-estimation of the parasite burden. The WBCs of individual patients should always be estimated when parasite density is required.