VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells
VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells
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DOI：
10.1093/emboj/18.14.3964
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发表时间：
1999-07-15
期刊：
影响因子：
11.4
通讯作者：
Isner, JM
中科院分区：
文献类型：
--
作者：
Asahara, T;Takahashi, T;Isner, JM
血管内皮生长因子（VEGF）已被证明可以促进动物模型中的新血管形成，最近，在人类受试者。这一特征被认为完全是由于其对完全分化的内皮细胞的直接作用，即血管生成。鉴于其在胎儿发育过程中的血管生成和血管发生中的调节作用，我们研究了VEGF可能调节内皮祖细胞（EPC）动力学以促进出生后新生血管形成的假设。事实上，我们观察到体内VEGF给药后循环EPCs增加。VEGF诱导的骨髓来源的EPCs的动员导致体外分化的EPCs增加和体内角膜新生血管增加。因此，这些发现建立了一个新的作用，VEGF在出生后的新生血管形成，补充其已知的影响血管生成。
Vascular endothelial growth factor (VEGF) has been shown to promote neovascularization in animal models and, more recently, in human subjects. This feature has been assumed to result exclusively from its direct effects on fully differentiated endothelial cells, i.e. angiogenesis. Given its regulatory role in both angiogenesis and vasculogenesis during fetal development, we investigated the hypothesis that VEGF may modulate endothelial progenitor cell (EPC) kinetics for postnatal neovascularization, Indeed, we observed an increase in circulating EPCs following VEGF administration in vivo. VEGF-induced mobilization of bone marrow-derived EPCs resulted in increased differentiated EPCs irt vitro and augmented corneal neovascularization in vivo. These findings thus establish a novel role for VEGF in postnatal neovascularization which complements its known impact on angiogenesis.