Accessible pediatric neuroimaging using a low field strength MRI scanner
Accessible pediatric neuroimaging using a low field strength MRI scanner
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DOI：
10.1016/j.neuroimage.2021.118273
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发表时间：
2021-06-18
期刊：
影响因子：
5.7
通讯作者：
Williams, Steven C. R.
中科院分区：
文献类型：
--
作者：
Deoni, Sean C. L.;Bruchhage, Muriel M. K.;Williams, Steven C. R.
磁共振成像（MRI）在了解婴儿、儿童和青少年神经发育方面发挥了越来越重要的作用，为神经典型发育的发育模式以及与潜在精神病理学、学习障碍和其他神经系统疾病相关的发育模式提供了新的见解。此外，研究表明，儿童的身体和心理社会环境对大脑结构和功能的发育有影响。然而，这些研究中的一个限速并发症是现代MRI系统的高成本和基础设施要求。高成本意味着许多神经影像学研究通常包括不到100人，并且主要在高收入国家（HIC）的高资源医院和大学环境中进行。因此，我们对大脑发育的了解，特别是生活在中低收入国家（LMICs）的儿童的大脑发育相对有限。磁场小于100 mT的低场系统有望降低扫描成本并在全球范围内广泛采用，但常规低场儿科神经成像尚未得到证实。在这里，我们提出了第一个儿科MRI数据收集的低成本和可评估的64 mT扫描仪在儿童6周到16岁，并复制脑容量估计和发展轨迹来自3T MRI数据。虽然是初步的，这些结果说明了潜在的低场成像作为一个可行的补充，更传统的高场成像系统，和一个可以进一步提高我们的知识，在LMIC的神经发育营养不良，心理社会逆境，和其他环境暴露可能会深刻地影响大脑成熟。
Magnetic resonance imaging (MRI) has played an increasingly relevant role in understanding infant, child, and adolescent neurodevelopment, providing new insight into developmental patterns in neurotypical development, as well as those associated with potential psychopathology, learning disorders, and other neurological conditions. In addition, studies have shown the impact of a child's physical and psychosocial environment on developing brain structure and function. A rate-limiting complication in these studies, however, is the high cost and infrastructural requirements of modern MRI systems. High costs mean many neuroimaging studies typically include fewer than 100 individuals and are performed predominately in high resource hospitals and university settings within high income countries (HICs). As a result, our knowledge of brain development, particularly in children who live in lower and middle income countries (LMICs) is relatively limited. Low field systems, with magnetic fields less than 100mT offer the promise of lower scanning costs and wide-spread global adoption, but routine low field pediatric neuroimaging has yet to be demonstrated. Here we present the first pediatric MRI data collected on a low cost and assessable 64mT scanner in children 6 weeks to 16 years of age and replicate brain volumes estimates and developmental trajectories derived from 3T MRI data. While preliminary, these results illustrate the potential of low field imaging as a viable complement to more conventional high field imaging systems, and one that may further enhance our knowledge of neurodevelopment in LMICs where malnutrition, psychosocial adversities, and other environmental exposures may profoundly affect brain maturation.