Association between Low Protein Intake and Mortality in Patients with Type 2 Diabetes
Association between Low Protein Intake and Mortality in Patients with Type 2 Diabetes
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DOI：
10.3390/nu12061629
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发表时间：
2020-06
期刊：
影响因子：
5.9
通讯作者：
T. Yamaoka;A. Araki;Y. Tamura;Shiro Tanaka;K. Fujihara;C. Horikawa;Rei Aida;Chiemi Kamada;Y. Yoshimura;T. Moriya;Y. Ohashi;Y. Akanuma;Hideki Ito;H. Sone
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作者：
T. Yamaoka;A. Araki;Y. Tamura;Shiro Tanaka;K. Fujihara;C. Horikawa;Rei Aida;Chiemi Kamada;Y. Yoshimura;T. Moriya;Y. Ohashi;Y. Akanuma;Hideki Ito;H. Sone
本研究的目的是调查蛋白质摄入量与2型糖尿病患者死亡风险之间的关系。我们分析了来自两项前瞻性纵向研究的2494例糖尿病患者的汇总数据。在基线时使用食物频率问卷评估营养摄入。将每天每体重（kg）的蛋白质摄入量分为四分位数组。使用考克斯回归分析计算校正的风险比（HR）和95%置信区间（CI）。在6年的随访中，有152例全因死亡事件。校正协变量后，与最高四分位数相比，每体重蛋白质摄入量最低四分位数的死亡率HR为2.26（95% CI：1.34-3.82，p = 0.002）。亚组分析显示，75岁以上或65岁以下患者的低蛋白质摄入量与死亡率之间存在显著相关性。在进一步调整总能量摄入后，≥ 75岁患者的蛋白质摄入量与死亡率之间仍存在显著相关性，而< 65岁患者的相关性减弱。我们的研究结果表明，足够的蛋白质摄入是必要的，在老年糖尿病患者超过75岁，而糖尿病，而整个最佳的总能量摄入是需要在年轻的2型糖尿病患者。
The aim of this study was to investigate the association between protein intake and mortality risk in patients with type 2 diabetes. We analyzed a pooled data of 2494 diabetic patients from two prospective longitudinal studies. Nutritional intake was assessed using a Food Frequency Questionnaire at baseline. Protein intake per body weight (kg) per day was categorized into quartile groups. Adjusted hazard ratios (HRs) and 95% confidence interval (CI) were calculated using Cox regression analysis. During the six-year follow-up, there were 152 incidents of all-cause mortality. The HR for mortality in the lowest quartile of protein intake per body weight compared with the highest quartile was 2.26 (95% CI: 1.34–3.82, p = 0.002) after adjustment for covariates. Subgroup analyses revealed significant associations between low protein intake and mortality in patients aged over 75 years or under 65 years. After further adjustment of the total energy intake, a significant association between protein intake and mortality remained in patients aged ≥ 75 years, whereas the association was attenuated in those aged < 65 years. Our results suggest that adequate protein intake is necessary in older diabetic patients over 75 years, whereas with diabetes, whereas whole optimal total energy intake is required in younger patients with type 2 diabetes.