The effects of sodium hyaluronate, chondroitin sulfate, and methylcellulose on the corneal endothelium and intraocular pressure.
The effects of sodium hyaluronate, chondroitin sulfate, and methylcellulose on the corneal endothelium and intraocular pressure.
复制标题
透明质酸钠、硫酸软骨素和甲基纤维素对角膜内皮和眼内压的影响。
DOI：
10.1016/s0002-9394(14)78301-1
复制
发表时间：
1983
影响因子：
4.2
通讯作者：
Schultz,RO
中科院分区：
文献类型：
--
作者：
MacRae,SM;Edelhauser,HF;Hyndiuk,RA;Burd,EM;Schultz,RO
透明质酸钠（Healon）、硫酸软骨素和甲基纤维素已被用于保护角膜内皮免受眼内晶状体损伤。对这些化合物的功效和毒性的研究表明，1%透明质酸钠、0.4%甲基纤维素和20%硫酸软骨素对角膜内皮无毒，但20%硫酸软骨素由于其高渗性会导致角膜厚度显着减少。前房注射这些粘性物质导致眼内压升高。在 1 至 4 小时内，1% 透明质酸钠的最大眼压为 67 ± 4.1 mm Hg，20% 硫酸软骨素的最大眼压为 55 ± 3.5 mm Hg。使用 10% 硫酸软骨素或 0.4% 甲基纤维素或将测试物质从前房冲洗出来时，眼内压不会增加到如此高的水平。 1%透明质酸钠和20%硫酸软骨素可保护角膜内皮免受损伤，但10%硫酸软骨素和0.4%甲基纤维素仅提供最低限度的保护。
Sodium hyaluronate (Healon), chondroitin sulfate, and methylcellulose have been used to protect the corneal endothelium from intraocular lens trauma. A study of the efficacy and toxicity of these compounds showed that 1% sodium hyaluronate, 0.4% methylcellulose, and 20% chondroitin sulfate were nontoxic to the corneal endothelium, but that 20% chondroitin sulfate caused a marked decrease in corneal thickness because of its hypertonicity. Anterior chamber injection of these viscous substances resulted in an increase in intraocular pressure. Within one to four hours the maximum intraocular pressure with 1% sodium hyaluronate was 67 ± 4.1 mm Hg and that with 20% chondroitin sulfate was 55 ± 3.5 mm Hg. The intraocular pressure did not increase to these high levels with 10% chondroitin sulfate or 0.4% methylcellulose or when the test substances were washed out of the anterior chamber. The corneal endothelium was protected from injury with 1% sodium hyaluronate and 20% chondroitin sulfate, but 10% chondroitin sulfate and 0.4% methylcellulose provided only minimal protection.