Bugs on a Slippery Plane : Understanding the Motility of Microbial Pathogens with Mathematical Modelling.

Bugs on a Slippery Plane : Understanding the Motility of Microbial Pathogens with Mathematical Modelling.
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滑平面上的虫子:通过数学模型了解微生物病原体的运动性。

DOI:
10.1007/978-3-319-32189-9_12
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发表时间:
2016
影响因子:
--
通讯作者:
Pushkin DO
Pushkin DO
中科院分区:
医学4区
文献类型:
--
作者:
Pushkin DO

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Many pathogenic microorganisms live in close association with surfaces, typically in thin films that either arise naturally or that they themselves create. In response to this constrained environment, the cells adjust their behaviour and morphology, invoking communication channels and inducing physical phenomena that allow for rapid colonization of biomedically relevant surfaces or the promotion of virulence factors. Thus, it is very important to measure and theoretically understand the key mechanisms for the apparent advantage obtained from swimming in thin films. We discuss experimental measurements of flows around a peritrichously flagellated bacterium constrained in a thin film, derive a simplified mathematical theory and Green’s functions for flows in a thin film with general slip boundary conditions, and establish connections between theoretical and experimental results. This article aims to highlight the importance of mathematics as a tool to unlock qualitative mechanisms associated with experimental observations in the medical and biological sciences.
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