MicroRNA Regulation of Oxidative Stress-Induced Cellular Senescence.
MicroRNA Regulation of Oxidative Stress-Induced Cellular Senescence.
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DOI：
10.1155/2017/2398696
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发表时间：
2017
影响因子：
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通讯作者：
Jansen-Dürr P
中科院分区：
文献类型：
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作者：
Bu H;Wedel S;Cavinato M;Jansen-Dürr P
衰老是细胞、组织、细胞器和有机体水平上与时间相关的功能退化过程，最终导致生命的结束。细胞衰老是一种永久性的细胞生长停滞状态，是对细胞应激的反应，被认为是衰老过程和年龄相关疾病的驱动因素。自由基衰老理论，下文称为氧化应激（OS）理论，是研究最多的衰老促进机制之一。此外，遗传学和表观遗传学在加速和/或延缓衰老和衰老相关疾病的发生方面也发挥着重要作用。在各种表观遗传事件中，microRNAs （miRNAs）在控制OS、衰老和细胞衰老中发挥着重要作用。mirna可以产生快速和可逆的反应，因此，通过其微调基因表达的能力，是介导对压力的适应性反应的理想参与者。然而，在衰老和细胞衰老的背景下，mirna在调节OS中的重要性在很大程度上是未知的。本文的目的是强调mirna在os诱导的细胞衰老中的调节作用的最新进展。
Aging is a time-related process of functional deterioration at cellular, tissue, organelle, and organismal level that ultimately brings life to end. Cellular senescence, a state of permanent cell growth arrest in response to cellular stress, is believed to be the driver of the aging process and age-related disorders. The free radical theory of aging, referred to as oxidative stress (OS) theory below, is one of the most studied aging promoting mechanisms. In addition, genetics and epigenetics also play large roles in accelerating and/or delaying the onset of aging and aging-related diseases. Among various epigenetic events, microRNAs (miRNAs) turned out to be important players in controlling OS, aging, and cellular senescence. miRNAs can generate rapid and reversible responses and, therefore, are ideal players for mediating an adaptive response against stress through their capacity to fine-tune gene expression. However, the importance of miRNAs in regulating OS in the context of aging and cellular senescence is largely unknown. The purpose of our article is to highlight recent advancements in the regulatory role of miRNAs in OS-induced cellular senescence.