Mast cell regulation of the immune response.
Mast cell regulation of the immune response.
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DOI：
10.1097/wox.0b013e3181c2a95e
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发表时间：
2009-10
期刊：
影响因子：
--
通讯作者：
Macey MR
中科院分区：
文献类型：
--
作者：
Ryan JJ;Morales JK;Falanga YT;Fernando JF;Macey MR
Mast cells are well known as principle effector cells of type I hypersensitivity responses. Beyond this role in allergic disease, these cells are now appreciated as playing an important role in many inflammatory conditions. This review summarizes the support for mast cell involvement in resisting bacterial infection, exacerbating autoimmunity and atherosclerosis, and promoting cancer progression. A commonality in these conditions is the ability of mast cells to elicit migration of many cell types, often through the production of inflammatory cytokines such as tumor necrosis factor. However, recent data also demonstrates that mast cells can suppress the immune response through interleukin-10 production. The data encourage those working in this field to expand their view of how mast cells contribute to immune homeostasis.
