Psoriatic arthritis: epidemiology, clinical features, course, and outcome
Psoriatic arthritis: epidemiology, clinical features, course, and outcome
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DOI：
10.1136/ard.2004.032482
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发表时间：
2005-03-01
影响因子：
27.4
通讯作者：
Nash, P
中科院分区：
文献类型：
--
作者：
Gladman, DD;Antoni, C;Nash, P
银屑病关节炎（PsA）是一种与银屑病相关的独特的炎症性关节炎。其确切的患病率尚不清楚，但估计在人口的0.3%至1%之间。最初描述的临床特征被大多数有经验的临床医生所认可，尽管它们在早期疾病中最明显。最初，PsA通常表现为少关节和轻度疾病。然而，随着时间的推移，PsA变成多关节的，并且在至少20%的患者中是严重的疾病。存在多关节疾病的PsA患者存在疾病进展的风险。除了临床和放射性损伤的进展外，PsA患者的健康相关生活质量也降低。值得注意的是，最近药物试验中纳入的患者与临床前瞻性随访的患者相似。
Psoriatic arthritis (PsA) has been defined as a unique inflammatory arthritis associated with psoriasis. Its exact prevalence is unknown, but estimates vary from 0.3% to 1% of the population. The clinical features described initially are recognised by most experienced clinicians, although they are most distinct in early disease. Initially, PsA typically presents as an oligoarticular and mild disease. However, with time PsA becomes polyarticular, and it is a severe disease in at least 20% of patients. Patients with PsA who present with polyarticular disease are at risk for disease progression. In addition to progression of clinical and radiological damage, health related quality of life is reduced among patients with PsA. It important to note that patients included in recent drug trials resemble patients followed prospectively in a clinic.