NEUROPEPTIDES AND INTERLEUKIN-6 IN HUMAN JOINT INFLAMMATION - RELATIONSHIP BETWEEN INTRAARTICULAR SUBSTANCE-P AND INTERLEUKIN-6 CONCENTRATIONS
NEUROPEPTIDES AND INTERLEUKIN-6 IN HUMAN JOINT INFLAMMATION - RELATIONSHIP BETWEEN INTRAARTICULAR SUBSTANCE-P AND INTERLEUKIN-6 CONCENTRATIONS
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DOI：
10.1016/0304-3940(94)90331-x
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发表时间：
1994-04-11
影响因子：
2.5
通讯作者：
HERNANZ, A
中科院分区：
文献类型：
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作者：
ARNALICH, F;DEMIGUEL, E;HERNANZ, A
采用酶联免疫吸附试验测定了18例类风湿关节炎和20例膝关节骨关节炎患者血浆和滑液中白细胞介素-6（IL-6）的浓度，以及降钙素基因相关肽（CGRP）、P物质和血管活性肠肽（VIP）的免疫反应水平。IL-6的浓度升高，血浆和滑液中的类风湿关节炎患者，而更高水平的P物质，CGRP和VIP样免疫反应被发现在滑液中，但不是在血浆中，类风湿关节炎患者相比，在骨关节炎。此外，在类风湿关节炎和骨关节炎患者中，滑液中的IL-6和P物质水平均显著相关。我们的数据似乎支持神经肽和IL-6在人类炎症性关节疾病的发病机制中发挥重要作用的想法。
Plasma and synovial fluid concentrations of interleukin-6 (IL-6), using an enzyme-linked immunosorbent assay, as well as immunoreactive levels of calcitonin gene-related peptide (CGRP), substance P and vasoactive intestinal peptide (VIP) were measured in 18 patients with rheumatoid arthritis and 20 with osteoarthritis of the knee. The concentrations of IL-6 were elevated in both plasma and synovial fluids from patients with rheumatoid arthritis whereas higher levels of substance P-, CGRP- and VIP-like immunoreactivities were found in the synovial fluid, but not in plasma, from patients with rheumatoid arthritis when compared with those in osteoarthritis. Furthermore, IL-6 and substance P levels in synovial fluid were significantly correlated both in rheumatoid arthritis and osteoarthritis patients. Our data seem to support the idea of an important role shared by neuropeptides and IL-6 in the pathogenesis of human inflammatory joint disease.