Psychiatric disorders in the biological and adoptive families of adopted individuals with affective disorders.
Psychiatric disorders in the biological and adoptive families of adopted individuals with affective disorders.
复制标题
被收养的患有情感障碍的个体的亲生家庭和收养家庭中的精神疾病。
DOI：
10.1001/archpsyc.1986.01800100013003
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发表时间：
1986
影响因子：
--
通讯作者：
I. Lunde
中科院分区：
文献类型：
--
作者：
P. Wender;S. Kety;D. Rosenthal;F. Schulsinger;J. Ortmann;I. Lunde
为了调查情绪障碍病因学中遗传和环境因素的贡献，启动了一项研究，以检查患有情绪障碍的成年被收养者的生物和收养亲属以及匹配的正常被收养者中精神障碍的频率。对亲属的精神病评估是根据精神病院和其他官方记录进行的独立盲法诊断作出的。数据分析显示，指示病例的生物亲属中的单相抑郁症增加了8倍，而指示病例的生物亲属中的自杀率增加了15倍。这些数据表明，一个显着的遗传贡献单相抑郁症和自杀。他们未能揭示一个显着的贡献，家庭相关的传播的起源的情绪障碍。
To investigate the contribution of genetic and environmental factors in the etiology of mood disorders, a study was initiated to examine the frequency of psychiatric disorders in the biological and adoptive relatives of adult adoptees with mood disorders and in matched normal adoptees. Psychiatric evaluations of the relatives were made on the basis of independent blind diagnoses based on mental hospital and other official records. Analysis of the data showed an eightfold increase in unipolar depression among the biological relatives of the index cases and a 15-fold increase in suicide among the biological relatives of the index cases. These data demonstrate a significant genetic contribution to unipolar depression and suicide. They fail to disclose a significant contribution of family-associated transmission in the genesis of the mood disorders.
影响因子：
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作者：
vonKnorring,AL;Cloninger,CR;Bohman,M;Sigvardsson,S
通讯作者：
Sigvardsson,S
苯乙肼 v 丙咪嗪治疗非典型抑郁症。
影响因子：
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作者：
Liebowitz,MR;Quitkin,FM;Stewart,JW;McGrath,PJ;Harrison,W;Rabkin,J;Tricamo,E;Markowitz,JS;Klein,DF
通讯作者：
Klein,DF
影响因子：
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作者：
Boyd,JH;Weissman,MM
通讯作者：
Weissman,MM