The prevalence of vitamin D abnormalities in South Asians with type 2 diabetes mellitus in the UK
The prevalence of vitamin D abnormalities in South Asians with type 2 diabetes mellitus in the UK
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DOI：
10.1111/j.1742-1241.2009.02221.x
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发表时间：
2010-02-01
影响因子：
2.6
通讯作者：
Bates, A.
中科院分区：
文献类型：
--
作者：
Tahrani, A. A.;Ball, A.;Bates, A.
背景：亚洲社区维生素D缺乏症和2型糖尿病（T2DM）的高患病率是众所周知的，但糖尿病对维生素D状态的影响，反之亦然，尚未有很好的报道。目的：了解亚洲2型糖尿病患者维生素D缺乏症的患病率及其对血糖控制的影响。方法：横断面研究在英国三级转诊中心进行。210名年龄在40岁以上的亚洲患者被纳入研究（170名患有T2DM， 40名没有T2DM）。每个人都有标准的骨骼特征（血清钙，磷酸盐和碱性磷酸酶），血清甲状旁腺激素和25-羟基胆钙化醇。结果：25-羟基维生素D低（< 50 nmol/l）的发生率在整个组中较高（> 80%），在糖尿病患者中较对照组更常见（83%比70%，p = 0.07）。男性尤其如此（82.5% vs. 57.9%; p = 0.02）。维生素D缺乏的女性HbA1c较高（< 12.5 nmol/l） （8.11 +/- 1.11% vs. 7.33 +/- 1.32%, p = 0.046）。在logistic回归分析中，T2DM是维生素D缺乏症的独立预测因子。在线性回归分析中，维生素D缺乏与T2DM女性的HbA1c独立相关。结论：维生素D缺乏症在亚洲人群中仍然是一个主要的公共卫生问题，并且在T2DM患者中被夸大了。维生素D缺乏的女性有较高的HbA1c水平，这一事实提高了维生素D替代可能改善血糖控制的可能性。
P>Background:The high prevalence of both hypovitaminosis D and type 2 diabetes (T2DM) in the Asian community is well recognised, but the impact of diabetes on vitamin D status and vice versa, has not been well reported.Aims:To determine the prevalence of hypovitaminosis D in Asian patients with T2DM and its impact on glycaemic control.Methods:A cross-sectional study was conducted in a tertiary referral centre in the UK. Two hundred and ten Asian patients aged more than 40 years were included (170 with and 40 without T2DM). Each had a standard bone profile (serum calcium, phosphate and alkaline phosphatase), serum parathyroid hormone and 25-hydroxycholecalciferol.Results:The prevalence of low serum 25-hydroxyvitamin D (< 50 nmol/l) was high in the group as a whole (> 80%) and more common in diabetics compared with controls (83% vs. 70%; p = 0.07). This was particularly so in men (82.5% vs. 57.9%; p = 0.02). HbA1c was higher in women with vitamin D deficiency (< 12.5 nmol/l) (8.11 +/- 1.11% vs. 7.33 +/- 1.32%, p = 0.046). In logistic regression analysis, T2DM was an independent predictor of hypovitaminosis D. In linear regression analysis, vitamin D deficiency was independently related to HbA1c in women with T2DM.Conclusions:Hypovitaminosis D remains a major public health issue in the Asian population and is exaggerated in patients with T2DM. The fact that vitamin D deficient women had higher HbA1c levels raises the possibility that vitamin D replacement may improve glycaemic control.