HEMORRHAGIC-FEVER WITH RENAL SYNDROME CAUSED BY THE SEOUL VIRUS
HEMORRHAGIC-FEVER WITH RENAL SYNDROME CAUSED BY THE SEOUL VIRUS
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作者：
KIM, YS;AHN, C;LEE, PW
首尔病毒是肾综合征出血热(HFRS)的重要病原体，首尔病毒的感染没有汉滩病毒那么严重。然而，有关首尔病毒引起的肾综合征出血热的信息在韩国有限。对1986~1991年在首尔国立大学医院就诊的30例汉城病毒感染者的临床资料进行了回顾性分析。他们与69名汉滩病毒感染患者进行了比较。汉城病毒是25%的韩国肾综合征出血热的病原体，是夏季肾综合征出血热的主要原因，尽管全年都有感染。与汉滩病毒感染相比，首尔病毒感染的出血和肾脏紊乱程度较轻，但肝功能障碍较严重。肾组织病理学结果显示，与汉滩病毒感染相比，出血和血管改变的程度较轻，但首尔病毒感染导致血管功能障碍和器官受累的确切机制仍有待探讨。
The Seoul virus is an important etiologic agent in hemorrhagic fever with renal syndrome (HFRS), and infections with the Seoul virus are less severe than those with the Hantaan virus. However, the information on HFRS caused by the Seoul virus is limited in Korea. Retrospective clinical analysis was done on 30 patients with Seoul virus infection who had been diagnosed as having HFRS by clinical features and serologic testing by the plaque reduction neutralization test from 1986 to 1991 at the Seoul National University Hospital. They were compared with 69 patients with Hantaan virus infection. The Seoul virus was the etiologic agent in 25 % of Korean HFRS and the major cause of HFRS during the summer season although infections occurred throughout the year. The Seoul virus infection had a milder degree of bleeding and renal derangement but had severer liver dysfunction than the Hantaan virus infection. Renal histopathologic findings revealed a milder degree of hemorrhage and vascular changes than cases involving Hantaan virus infection, The precise mechanisms of vascular dysfunction and organ involvement in Seoul virus infection, however, still remain to be explored.