THE NOD MOUSE - RECESSIVE DIABETOGENIC GENE IN THE MAJOR HISTOCOMPATIBILITY COMPLEX
THE NOD MOUSE - RECESSIVE DIABETOGENIC GENE IN THE MAJOR HISTOCOMPATIBILITY COMPLEX
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DOI：
10.1126/science.3003909
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发表时间：
1986-02-14
期刊：
影响因子：
56.9
通讯作者：
EISENBARTH, GS
中科院分区：
文献类型：
--
作者：
HATTORI, M;BUSE, JB;EISENBARTH, GS
用抗II类糖蛋白抗体检测非肥胖糖尿病（NOD）小鼠的组织相容性区域（主要组织相容性复合体I-A和I-E的免疫应答基因的产物）、杂交T细胞克隆和混合淋巴细胞培养物以及限制性片段长度多态性分析表明NOD小鼠具有独特的II类主要组织相容性复合体，不表达表面I-E，没有I-E α的信使RNA，和不被所研究的任何单克隆抗体或杂交T细胞克隆识别的I-A。在NOD小鼠与对照C3 H小鼠的杂交中，糖尿病的发展依赖于NOD小鼠独特的主要组织相容性区域的纯合性。
Examination of the histocompatibility region of the nonobese diabetic (NOD) mouse with antibodies against class II glycoproteins (products of immune response genes of the major histocompatibility complex I-A and I-E), hybrid T-cell clones, and mixed-lymphocyte cultures and analysis of restriction fragment length polymorphisms indicate that the NOD mouse has a unique class II major histocompatibility complex with no expression of surface I-E, no messenger RNA for I-E.alpha., and an I-A not recognized by any monoclonal antibodies or hybrid T-cell clones studied. In crosses of NOD mice with control C3H mice, the development of diabetes was dependent on homozygosity for the NOD mouse''s unique major histocompatibility region.