Male hormonal contraception.
Male hormonal contraception.
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DOI：
10.1001/virtualmentor.2012.14.2.stas1-1202
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发表时间：
2012-02-01
期刊：
影响因子：
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通讯作者：
Roth, Mara Y
中科院分区：
文献类型：
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作者：
Roth, Mara Y
在世界各地，包括美国，所有怀孕的一半是计划外的，导致不安全的堕胎和成千上万的健康年轻女性不必要的死亡[1，2]。虽然女性的可逆避孕选择已经激增，包括药丸，贴片，注射，宫内节育器和永久绝育[3]，但自从400多年前避孕套的发展以来，没有新的可逆避孕选择出现在男性身上。尽管多个种族、宗教和民族的男性和女性都对可逆的激素避孕药表示了兴趣[4，5]，但仍然没有商业上可用的选择。本文将综述可逆性男性激素避孕药的理论、目前正在开发的药物以及潜在的风险和益处。
Throughout the world, including the United States, one-half of all pregnancies are unplanned, leading to unsafe abortions and the unnecessary deaths of thousands of healthy young women [1, 2]. While reversible contraceptive options for women have proliferated to include pills, patches, injections, intrauterine devices, and permanent sterilization [3], no new reversible contraceptive options have arisen for men since the development of condoms over 400 years ago. Despite expressions of interest in a reversible hormonal contraceptive for men by men and women of multiple races, religions, and ethnicities [4, 5], there is still no commercially available option. This article will review the theory, the current agents in development, and the potential risks and benefits of a reversible male hormonal contraceptive.