Emerging roles of ATF2 and the dynamic AP1 network in cancer
Emerging roles of ATF2 and the dynamic AP1 network in cancer
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DOI：
10.1038/nrc2846
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发表时间：
2010-05
影响因子：
78.5
通讯作者：
P. Lopez-Bergami;E. Lau;Z. Ronai
中科院分区：
文献类型：
--
作者：
P. Lopez-Bergami;E. Lau;Z. Ronai
转录因子之间的合作对它们执行特定转录程序的能力至关重要。AP1复合体例证了一个转录因子网络，在正常情况下和在肿瘤发生和进展过程中一致发挥作用。本展望总结了我们目前对AP1复合体成员的变化以及作为该复合体一部分的ATF2在肿瘤发生中的作用的理解。
Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal circumstances and during the course of tumour development and progression. This Perspective summarizes our current understanding of the changes in members of the AP1 complex and the role of ATF2 as part of this complex in tumorigenesis.