Left atrial flow velocity distribution and flow coherence using four-dimensional FLOW MRI: A pilot study investigating the impact of age and Pre- and Postintervention atrial fibrillation on atrial hemodynamics
Left atrial flow velocity distribution and flow coherence using four-dimensional FLOW MRI: A pilot study investigating the impact of age and Pre- and Postintervention atrial fibrillation on atrial hemodynamics
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DOI：
10.1002/jmri.23994
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发表时间：
2013-09-01
影响因子：
4.4
通讯作者：
Markl, Michael
中科院分区：
文献类型：
--
作者：
Fluckiger, Jacob U.;Goldberger, Jeffrey J.;Markl, Michael
目的：应用四维(4D)Flow MRI对有房颤病史的患者左心房(LA)的三维血流进行定性和定量。材料和方法：19例志愿者(n=950岁)和10例房颤患者(62+/-9.6岁，n=4例持续性房颤，n=6例介入后)进行了4D Flow MRI检查。对每个数据集的左房进行分割，并量化房内血流速度。血流一致性以净血流向量的一致性来衡量。结果：心房血流定量显示不同年龄组之间的心房血流动力学有显著差异。干预后房颤患者的平均血流量为0.22+/-0.04m/S，与年龄匹配的正常人(0.21+/-0.03m/S)比较差异无统计学意义。持续性房颤患者的平均血流量为0.13±0.01m/S，低于窦性心律房颤患者(0.22±0.04m/S，P=0.005)和年龄匹配的正常人(0.21±0.03m/S，P<；0.001)。结论：血流敏感的MRI显示有房颤病史的患者与年龄匹配的志愿者在左房的整体血流动力学相似。需要对更多的房颤患者进行更多的队列研究，以及与预后的相关性，以进一步研究心房4D血流MRI对反映房颤卒中风险的血流模式的潜力。J·马根。雷森。成像2013；38：580-587。(C)2013年威利期刊公司。
Purpose: To use four-dimensional (4D) flow MRI to characterize and quantify 3D blood flow in the left atria (LA) of patients with a history of atrial fibrillation (AF).Materials and Methods: The 4D flow MRI was acquired in 19 volunteers (n = 950 years) and 10 patients with AF (62 +/- 9.6 years; n = 4 in persistent AF, n = 6 postintervention). The LA in each dataset was segmented, and intra-atrial blood flow velocity was quantified. Flow coherence was measured as the consistency of the net blood flow vector.Results: Quantification of atrial flow revealed significant differences in atrial hemodynamics between age groups. Postintervention AF patients had a mean blood flow of 0.22 +/- 0.04 m/s, which was not significantly different than age-matched volunteers (0.21 +/- 0.03 m/s). Patients with persistent AF had a mean blood flow of 0.13 +/- 0.01 m/s, lower than AF patients in sinus rhythm (0.22 +/- 0.04 m/s, P = 0.005), or age-matched volunteers (0.21 +/- 0.03 m/s, P < 0.001). Flow coherence was significantly impaired in patients in AF.Conclusion: Flow-sensitive MRI shows that patients with a history of AF had global hemodynamics in the LA similar to those of age-matched volunteers. Additional studies with larger cohorts of AF patients and correlation with outcome are needed to further investigate the potential of atrial 4D flow MRI to flow patterns indicative of stroke risk in AF. J. Magn. Reson. Imaging 2013;38:580-587. (c) 2013 Wiley Periodicals, Inc.