Differential involvement of the Mu and Kappa opioid receptors in spatial learning
Differential involvement of the Mu and Kappa opioid receptors in spatial learning
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DOI：
10.1034/j.1601-183x.2003.00013.x
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发表时间：
2003-04-01
影响因子：
2.5
通讯作者：
Roder, JC
中科院分区：
文献类型：
--
作者：
Jamot, L;Matthes, HWD;Roder, JC
为了测试Mu和Kappa阿片受体(Mu阿片受体和Kappa阿片受体)在海马区依赖的空间学习中的作用，我们分析了缺失功能性Mor和KOR基因的基因工程零突变小鼠。与野生型小鼠相比，纯合子Mor缺失突变体在两个不同的任务--8臂径向迷宫和Morris水迷宫中显示出最终的空间学习水平受损。控制行为正常。学习障碍可能与我们在CA3区苔藓纤维的长时程增强维持过程中发现的障碍有关。相比之下，我们的KOR突变体或CA3区长时程增强(LTP)中的苔藓纤维(MF)在空间学习方面没有损害。我们的工作表明，MOR可能通过增加CA3神经元的LTP而在学习和记忆中发挥积极作用。
In order to test the role of mu and kappa opioid receptors (Mu opioid receptor (MOR) and Kappa opioid receptor (KOR)) in hippocampal-dependent spatial learning, we analyzed genetically engineered null mutant mice missing the functional MOR or KOR gene. Compared to wild-type mice, the homozygous MOR null mutants exhibited an impairment in the ultimate level of spatial learning as shown in two distinct tasks, the 8-arm radial-maze and the Morris water-maze. Control behaviors were normal. The learning impairment could be associated with the impairment we found in the maintenance of long-term potentiation in mossy fibers in CA3. In comparison, there was no impairment in spatial learning in our KOR mutants or in mossy fibers (mf) in CA3 region long-term potentiation (LTP). Our work suggests that the MOR may play a positive role in learning and memory by increasing LTP in CA3 neurons.