Clinicopathologic features and time interval analysis of contralateral breast cancers
Clinicopathologic features and time interval analysis of contralateral breast cancers
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DOI：
10.1016/j.surg.2015.03.059
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发表时间：
2015-09-01
期刊：
影响因子：
3.8
通讯作者：
Yao, Katharine
中科院分区：
文献类型：
--
作者：
Liederbach, Erik;Piro, Rita;Yao, Katharine
Introduction. We hypothesized that most contralateral breast cancers (CBCs) develop >= 5 years after the primary breast cancer (PBC) and that CBCs have more favorable tumor characteristics.Methods. This is a single-institution retrospective review of 323 patients who were diagnosed with CBC from 1990 to 2014. CBCs were diagnosed at least I year after the diagnosis of PBC. X-2 tests and one-way analysis of variance were used to examine the time interval and pathologic features between the PBC and CBC.Results. The median time interval between the PBC and CBC was 6.2 years (average: 7.1, range: 1.01-23.0), and 189 (58.5%) patients had a time interval >= 5 years. Patients >= 70 years old developed a CBC sooner than patients 1 cm larger than their PBC, and only 25 (9.9%) patients developed a CBC that was >2 cm larger than their PBC. Only 28 of 201 (13.9%) node-negative PBCs developed a node-positive CBC.Conclusion. A majority of CBCs develop >= 5 years after the diagnosis of the PBC CBCs have more favorable tumor characteristics than the PBC and tend to be smaller and node negative.
