Elevated content of cortisol in hair of patients with severe chronic pain: A novel biomarker for stress
Elevated content of cortisol in hair of patients with severe chronic pain: A novel biomarker for stress
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DOI：
10.1080/10253890801887388
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发表时间：
2008-01-01
影响因子：
2.3
通讯作者：
Koren, G.
中科院分区：
文献类型：
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作者：
Van Uum, S. H. M.;Sauve, B.;Koren, G.
头发分析已用于反映长期全身暴露于外源性药物和毒素的情况。几项研究已经证明了测量内源性类固醇激素的可行性，例如。 g。皮质醇，存在于头发中。最近，一项针对猕猴的研究表明，压力引起的毛发皮质醇水平显着增加。我们探讨了头发皮质醇水平是否可以用作人类长期压力的生物标志物。招募了年龄 18 岁或以上、接受阿片类药物治疗至少一年的严重慢性疼痛患者。对照组为非肥胖（体重指数，BMI < 30 mg/kg(2)）成年人。使用感知压力量表 (PSS) 问卷来评估过去 4 周的感知压力。从后顶点获取头发样本。使用酶联免疫吸附测定法测量皮质醇。我们纳入了 15 名患者（9 名女性和 6 名男性）和 39 名非肥胖对照受试者（20 名女性，19 名男性）。慢性疼痛患者 (24: 12-28) 的 PSS 评分（中位数和范围）显着高于对照组 (12: 3-31)（P < 0.001）。慢性疼痛患者的头发皮质醇含量（中位数和范围）（83.1：33.0-205 g/mg）显着高于对照组（46.1：27.2-200 pg/mg）（P < 0.01）。我们得出的结论是，患有严重慢性压力的患者头发皮质醇含量增加。头发中皮质醇水平的测量构成了长期压力的新型生物标志物。
Hair analysis has been used to reflect long-term systemic exposure to exogenous drugs and toxins. Several studies have demonstrated the feasibility of measuring endogenous steroid hormones, e. g. cortisol, in hair. Recently, a study in macaques showed a significant increase in hair cortisol levels induced by stress. We explored whether hair cortisol levels may be used as a biomarker for long-term stress in humans. Patients with severe chronic pain, aged 18 years or older, receiving opioid treatment for at least one year were recruited. Controls were non-obese (body mass index, BMI < 30 mg/kg(2)) adults. The Perceived Stress Scale (PSS) questionnaire was used to assess perceived stress over the last 4 weeks. A hair sample was obtained from the vertex posterior. Cortisol was measured using an enzyme-linked immunosorbent assay. We included fifteen patients (nine females and six males) and 39 non-obese control subjects (20 females, 19 males). PSS scores (median and range) were significantly higher in chronic pain patients (24: 12-28) than in controls (12: 3-31)(P < 0.001). Hair cortisol contents (median and range) were significantly greater in chronic pain patients (83.1: 33.0-205 g/mg) than in controls (46.1: 27.2-200 pg/mg) (P < 0.01). We conclude that hair cortisol contents are increased in patients with major chronic stress. Measurement of cortisol levels in hair constitutes a novel biomarker of prolonged stress.