Inhibitory Activity of Hydroxytyrosol against Streptolysin O-Induced Hemolysis
Inhibitory Activity of Hydroxytyrosol against Streptolysin O-Induced Hemolysis
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DOI：
10.4265/bio.23.77
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发表时间：
2018-06-01
影响因子：
1.2
通讯作者：
Fukuyama, Masafumi
中科院分区：
文献类型：
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作者：
Sogawa, Kazuyuki;Kobayashi, Mika;Fukuyama, Masafumi
A组链球菌是一种存在于咽喉和皮肤的细菌，可引起呼吸道感染，偶尔还会引发肾小球肾炎和风湿热。化脓性链球菌产生的链球菌溶血素O（SLO）会与细胞膜结合，尤其是白细胞和红细胞的细胞膜，并且对细胞和组织有毒性。在这项研究中，我们评估了橄榄（油橄榄）中水溶性多酚对SLO诱导的溶血的抑制活性。羟基酪醇抑制了SLO诱导的溶血活性，抑制50%溶血所需的量为1.30微克。这些发现表明，橄榄中含有的水溶性多酚对SLO诱导的溶血具有抑制活性。
Group A streptococcus is a bacterium that resides in the throat and skin and causes respiratory infection and occasionally glomerulonephritis and rheumatic fever. Streptolysin O (SLO) produced by Streptococcus pyogenes (S. pyogenes) binds to the cell membrane, particularly to that of white and red blood cells, and is toxic to the cells and tissue. In this study, we evaluated the inhibitory activity of water-soluble polyphenols in olives (Olea europaea) against SLO-induced hemolysis. Hydroxytyrosol inhibited SLO-induced hemolytic activity, and the amount required for 50% inhibition of hemolysis was 1.30 mu g. These findings suggest that the water-soluble polyphenols contained in olives have inhibitory activity against SLO-induced hemolysis.