Electrostatically assembled polyelectrolyte/dendrimer multilayer films as ultrathin nanoreservoirs
Electrostatically assembled polyelectrolyte/dendrimer multilayer films as ultrathin nanoreservoirs
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DOI：
10.1021/nl015696o
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发表时间：
2002-04-01
期刊：
影响因子：
10.8
通讯作者：
Caruso, F
中科院分区：
文献类型：
--
作者：
Khopade, AJ;Caruso, F
我们报告的制备的双极性，多层的双极性/树枝状聚合物膜的顺序静电沉积的带负电荷的聚（苯乙烯磺酸盐）（PSS）和带正电荷的第四代聚（酰胺胺）树枝状聚合物（4G PAMAM）。首先在平面支撑物上构建多层膜以检查它们的逐层生长。石英晶体微天平（QCM）的测量结果表明，定期增长的每一层沉积，而紫外-可见分光光度法显示的吸附-脱附的趋势，薄膜的形成，与部分PSS去除沉积后的4G PAMAM。PSS/4G PAMAM膜随后构建在球形胶乳胶体。荧光光谱显示，当暴露于含染料的溶液中时，薄膜充当纳米储库，由于带相反电荷的树枝状聚合物的存在，将带电分子从溶液中隔离。随后通过在等渗盐水溶液中的浓度依赖性扩散实现了捕获的染料分子的释放，说明了基于树枝状聚合物的膜作为用于摄取和释放各种化合物的系统的潜力。
We report the preparation of loadable ultrathin, multilayered polyelectrolyte/dendrimer films by the sequential electrostatic deposition of negatively charged poly(styrenesulfonate) (PSS) and a positively charged fourth generation poly(amidoamine) dendrimer (4G PAMAM). Multilayers were first constructed on planar supports to examine their layer-by-layer growth. Quartz crystal microbalance (QCM) measurements showed regular growth for each layer deposited, while UV-vis spectrophotometry revealed an adsorption-desorption trend to film formation, with partial PSS removal upon deposition of 4G PAMAM. PSS/4G PAMAM films were subsequently constructed on spherical latex colloids. Fluorescence spectroscopy showed that the films, when exposed to dye-containing solutions, acted as nanoreservoirs, sequestering the charged molecules from solution due to the presence of the oppositely charged dendrimer. Release of the entrapped dye molecules was subsequently achieved by concentration-dependent diffusion in isotonic saline solutions, illustrating the potential of the dendrimer-based films as systems for the uptake and release of various compounds.